Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/200760
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Cerón Madrigal, Julián | - |
dc.contributor.author | Ahumada Brena, David Ricardo | - |
dc.date.accessioned | 2023-07-17T06:36:21Z | - |
dc.date.available | 2023-07-17T06:36:21Z | - |
dc.date.issued | 2021-07-09 | - |
dc.identifier.uri | http://hdl.handle.net/2445/200760 | - |
dc.description.abstract | [eng] Mammalian Inhibitor-of-kappa-B (IκBs) proteins exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for IκBs has been shown to affect stemness and cell differentiation. However, the involvement of NF-κB in this function has not been excluded. NFKI-1 and IKB1 are IκB homologs in aenorhabditis elegans, which lacks NF-κB nuclear effectors. We found that nfki-1 and ikb-1 mutants display developmental defects that phenocopy mutations in Polycomb and UTX-1 histone demethylase, suggesting a role for C. elegans IκBs in chromatin regulation. Further supporting this possibility (i) we detected NFKI-1 in the nucleus of cells; (ii) NFKI-1 and IKB-1 bind to histones and Polycomb proteins, (iii) and associate with chromatin in vivo, and (iv) mutations in nfki-1 and ikb-1 alter chromatin marks. Based on these results, we propose that ancestral IκB proteins modulate chromatin marks with an impact on development. | ca |
dc.format.extent | Universitat de Barcelona. Facultat de Medicina | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | Universitat de Barcelona | - |
dc.rights | cc by (c) Ahumada Brena, David Ricardo, 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Tesis Doctorals - Facultat - Medicina | - |
dc.subject.classification | Epigenètica | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Proteïnes supressores de tumors | - |
dc.subject.classification | Models animals en la investigació | - |
dc.subject.other | Epigenetics | - |
dc.subject.other | Cancer | - |
dc.subject.other | Tumor suppressor protein | - |
dc.subject.other | Animal models in research | - |
dc.title | Ancestral roles of IĸB proteins in Caenorhabditis elegans | ca |
dc.type | info:eu-repo/semantics/doctoralThesis | ca |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
dc.identifier.tdx | http://hdl.handle.net/10803/688664 | - |
Appears in Collections: | Tesis Doctorals - Facultat - Medicina |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
DRAB_PhD_THESIS.pdf | 4.53 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License