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DC Field | Value | Language |
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dc.contributor.author | Ruiz Hueso, Rocío | - |
dc.contributor.author | Salamanca Bautista, Prado | - |
dc.contributor.author | Quesada Simón, Maria Angustias | - |
dc.contributor.author | Yun, Sergi | - |
dc.contributor.author | Conde Martel, Alicia | - |
dc.contributor.author | Morales Rull, José Luis | - |
dc.contributor.author | Suárez Gil, Roi | - |
dc.contributor.author | García García, José Ángel | - |
dc.contributor.author | Llàcer, Pau | - |
dc.contributor.author | Fonseca Aizpuru, Eva María | - |
dc.contributor.author | Amores Arriaga, Beatriz | - |
dc.contributor.author | Martínez González, Ángel | - |
dc.contributor.author | Armengou Arxe, Arola | - |
dc.contributor.author | Peña Somovilla, José Luis | - |
dc.contributor.author | López Reboiro, Manuel Lorenzo | - |
dc.contributor.author | Aramburu Bodas, Óscar | - |
dc.contributor.author | PREVAMIC Investigators Group | - |
dc.date.accessioned | 2023-07-19T09:57:33Z | - |
dc.date.available | 2023-07-19T09:57:33Z | - |
dc.date.issued | 2023-03-15 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/2445/200879 | - |
dc.description.abstract | Background: Cardiac amyloidosis (CA) could be a common cause of heart failure (HF). The objective of the study was to estimate the prevalence of CA in patients with HF. Methods: Observational, prospective, and multicenter study involving 30 Spanish hospitals. A total of 453 patients >= 65 years with HF and an interventricular septum or posterior wall thickness > 12 mm were included. All patients underwent a Tc-99m-DPD/PYP/HMDP scintigraphy and monoclonal bands were studied, following the current criteria for non-invasive diagnosis. In inconclusive cases, biopsies were performed. Results: The vast majority of CA were diagnosed non-invasively. The prevalence was 20.1%. Most of the CA were transthyretin (ATTR-CM, 84.6%), with a minority of cardiac light-chain amyloidosis (AL-CM, 2.2%). The remaining (13.2%) was untyped. The prevalence was significantly higher in men (60.1% vs 39.9%, p = 0.019). Of the patients with CA, 26.5% had a left ventricular ejection fraction less than 50%. Conclusions: CA was the cause of HF in one out of five patients and should be screened in the elderly with HF and myocardial thickening, regardless of sex and LVEF. Few transthyretin-gene-sequencing studies were performed in older patients. In many patients, it was not possible to determine the amyloid subtype. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm12062273 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2023, vol. 12, num. 6, p. 2273 | - |
dc.relation.uri | https://doi.org/10.3390/jcm12062273 | - |
dc.rights | cc by (c) Ruiz Hueso, Rocío et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Amiloïdosi | - |
dc.subject.classification | Insuficiència cardíaca | - |
dc.subject.classification | Epidemiologia | - |
dc.subject.other | Amyloidosis | - |
dc.subject.other | Heart failure | - |
dc.subject.other | Epidemiology | - |
dc.title | Estimating the Prevalence of Cardiac Amyloidosis in Old Patients with Heart Failure—Barriers and Opportunities for Improvement: The PREVAMIC Study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-06-21T11:31:49Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 36983274 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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jcm-12-02273-v2.pdf | 1.1 MB | Adobe PDF | View/Open |
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