Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/200880
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hipke, Katrin | - |
dc.contributor.author | Pitter, Bettina | - |
dc.contributor.author | Hruscha, Alexander | - |
dc.contributor.author | van Bebber, Frauke | - |
dc.contributor.author | Modic, Miha | - |
dc.contributor.author | Bansal, Vikas | - |
dc.contributor.author | Lewandowski, Sebastian A. | - |
dc.contributor.author | Orozco, Denise | - |
dc.contributor.author | Edbauer, Dieter | - |
dc.contributor.author | Bonn, Stefan | - |
dc.contributor.author | Haass, Christian | - |
dc.contributor.author | Pohl, Ulrich | - |
dc.contributor.author | Montañez, Eloi | - |
dc.contributor.author | Schmid, Bettina | - |
dc.date.accessioned | 2023-07-19T08:52:06Z | - |
dc.date.available | 2023-07-19T08:52:06Z | - |
dc.date.issued | 2023-06-13 | - |
dc.identifier.issn | 2296-634X | - |
dc.identifier.uri | http://hdl.handle.net/2445/200880 | - |
dc.description.abstract | Aggregation of the Tar DNA-binding protein of 43 kDa (TDP-43) is a pathological hallmark of amyotrophic lateral sclerosis and frontotemporal dementia and likely contributes to disease by loss of nuclear function. Analysis of TDP-43 function in knockout zebrafish identified an endothelial directional migration and hypersprouting phenotype during development prior lethality. In human umbilical vein cells (HUVEC) the loss of TDP-43 leads to hyperbranching. We identified elevated expression of FIBRONECTIN 1 (FN1), the VASCULAR CELL ADHESION MOLECULE 1 (VCAM1), as well as their receptor INTEGRIN α4β1 (ITGA4B1) in HUVEC cells. Importantly, reducing the levels of ITGA4, FN1, and VCAM1 homologues in the TDP-43 loss-of-function zebrafish rescues the angiogenic defects indicating the conservation of human and zebrafish TDP-43 function during angiogenesis. Our study identifies a novel pathway regulated by TDP-43 important for angiogenesis during development. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fcell.2023.1169962 | - |
dc.relation.ispartof | Frontiers In Cell And Developmental Biology, 2023, vol. 11 | - |
dc.relation.uri | https://doi.org/10.3389/fcell.2023.1169962 | - |
dc.rights | cc-by (c) Hipke, Katrin et al., 2023 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Angiogènesi | - |
dc.subject.classification | Malalties neurodegeneratives | - |
dc.subject.classification | Peix zebra | - |
dc.subject.classification | Proteïnes | - |
dc.subject.other | Neovascularization | - |
dc.subject.other | Neurodegenerative Diseases | - |
dc.subject.other | Zebra danio | - |
dc.subject.other | Proteins | - |
dc.title | Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 737844 | - |
dc.date.updated | 2023-07-19T08:52:06Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 37384248 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
737844.pdf | 3.07 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License