Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/200920
Title: | Airway Complications after Lung Transplantation—A Contemporary Series of 400 Bronchial Anastomoses from a Single Center |
Author: | Muñoz Fos, Anna Moreno, Paula González, Francisco Javier Ruiz, Eloisa Vaquero, Jose Manuel Baamonde, Carlos Cerezo, Francisco Algar, Javier Ramos Izquierdo, Ricard Salvatierra, Ángel Alvarez, Antonio |
Keywords: | Trasplantament d'òrgans Pulmó Complicacions quirúrgiques Transplantation of organs Lung Complications of surgery |
Issue Date: | 23-Apr-2023 |
Publisher: | MDPI AG |
Abstract: | (1)Objective: To determine whether recent advances in lung transplantation (LT) have reduced the incidence and changed the risk factors for airway complications (AC). (2) Methods: Retrospective analysis of patients receiving a lung transplant between January 2007 and January 2019. An AC was defined as a bronchoscopic abnormality in the airway, either requiring or not requiring an endoscopic or surgical intervention. Both univariable and multivariable analyses were performed to identify risk factors for AC. (3) Results: 285 lung transplants (170 single and 115 bilateral lung transplants) were analysed, comprising 400 anastomoses at risk. A total of 50 anastomoses resulted in AC (12%). There were 14 anastomotic and 11 non-anastomotic stenoses, 4 dehiscences, and 3 malacias. Independent predictors for AC were: gender male (OR: 4.18; p = 0.002), cardiac comorbidities (OR: 2.74; p = 0.009), prolonged postoperative mechanical ventilation (OR: 2.5; p = 0.02), PaO2/FiO2 < 300 mmHg at 24 h post-LT (OR: 2.48; p = 0.01), graft infection (OR: 2.16; p = 0.05), and post-LT isolation of Aspergillus spp. (OR: 2.63; p = 0.03). (4) Conclusions: In spite of advances in lung transplantation practice, the risk factors, incidence, and lethality of AC after LT remains unchanged. Graft dysfunction, an infected environment, and the need of prolonged mechanical ventilation remain an Achilles heel for AC. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm12093061 |
It is part of: | Journal of Clinical Medicine, 2023, vol. 12, num. 9, p. 3061 |
URI: | http://hdl.handle.net/2445/200920 |
Related resource: | https://doi.org/10.3390/jcm12093061 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
jcm-12-03061.pdf | 271.91 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License