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http://hdl.handle.net/2445/200923
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DC Field | Value | Language |
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dc.contributor.author | Martínez Bosch, Neus | - |
dc.contributor.author | Vilariño, Noelia | - |
dc.contributor.author | Alameda, Francesc | - |
dc.contributor.author | Mojal, Sergi | - |
dc.contributor.author | Arumí Uria, Montserrat | - |
dc.contributor.author | Carrato, Cristina | - |
dc.contributor.author | Aldecoa Ansórregui, Iban | - |
dc.contributor.author | Ribalta Farrés, Teresa María | - |
dc.contributor.author | Vidal, Noemí | - |
dc.contributor.author | Bellosillo, Beatriz | - |
dc.contributor.author | Menéndez, Silvia | - |
dc.contributor.author | Barco, Sonia del | - |
dc.contributor.author | Gallego, Oscar | - |
dc.contributor.author | Pineda, Estela | - |
dc.contributor.author | López Martos, Raquel | - |
dc.contributor.author | Hernández, Ainhoa | - |
dc.contributor.author | Mesia, Carlos | - |
dc.contributor.author | Esteve Codina, Anna | - |
dc.contributor.author | Iglesia, Núria de la | - |
dc.contributor.author | Balañá, Carme | - |
dc.contributor.author | Martínez García, María | - |
dc.contributor.author | Navarro, Pilar | - |
dc.date.accessioned | 2023-07-19T11:34:59Z | - |
dc.date.available | 2023-07-19T11:34:59Z | - |
dc.date.issued | 2023-03-08 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.issn | 36980184 | - |
dc.identifier.uri | http://hdl.handle.net/2445/200923 | - |
dc.description.abstract | Glioblastoma (GBM) is the most frequent primary malignant brain tumor and has a dismal prognosis. Unfortunately, despite the recent revolution of immune checkpoint inhibitors in many solid tumors, these have not shown a benefit in overall survival in GBM patients. Therefore, new potential treatment targets as well as diagnostic, prognostic, and/or predictive biomarkers are needed to improve outcomes in this population. The beta-galactoside binding protein Galectin-1 (Gal-1) is a protein with a wide range of pro-tumor functions such as proliferation, invasion, angiogenesis, and immune suppression. Here, we evaluated Gal-1 expression by immunohistochemistry in a homogenously treated cohort of GBM (the GLIOCAT project) and correlated its expression with clinical and molecular data. We observed that Gal-1 is a negative prognostic factor in GBM. Interestingly, we observed higher levels of Gal-1 expression in the mesenchymal/classical subtypes compared to the less aggressive proneural subtype. We also observed a Gal-1 expression correlation with immune suppressive signatures of CD4 T-cells and macrophages, as well as with several GBM established biomarkers, including SHC1, PD-L1, PAX2, MEOX2, YKL-40, TCIRG1, YWHAG, OLIG2, SOX2, Ki-67, and SOX11. Moreover, Gal-1 levels were significantly lower in grade 4 IDH-1 mutant astrocytomas, which have a better prognosis. Our results confirm the role of Gal-1 as a prognostic factor and also suggest its value as an immune-suppressive biomarker in GBM. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/cells12060843 | - |
dc.relation.ispartof | Cells, 2023, vol. 12, num. 6 | - |
dc.relation.uri | https://doi.org/10.3390/cells12060843 | - |
dc.rights | cc by (c) Martínez Bosch, Neus et al, 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Glioma | - |
dc.subject.classification | Tumors cerebrals | - |
dc.subject.other | Gliomas | - |
dc.subject.other | Brain tumors | - |
dc.title | Gal-1 Expression Analysis in the GLIOCAT Multicenter Study: Role as a Prognostic Factor and an Immune-Suppressive Biomarker | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-06-21T12:20:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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cells-12-00843-v2.pdf | 3.01 MB | Adobe PDF | View/Open |
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