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http://hdl.handle.net/2445/201183
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DC Field | Value | Language |
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dc.contributor.author | Inguanzo, Anna | - |
dc.contributor.author | Poulakis, Konstantinos | - |
dc.contributor.author | Mohanty, Rosaleena | - |
dc.contributor.author | Schwarz, Christopher G. | - |
dc.contributor.author | Przybelski, Scott A. | - |
dc.contributor.author | Diaz Galvan, Patricia | - |
dc.contributor.author | Lowe, Val J. | - |
dc.contributor.author | Boeve, Bradley F. | - |
dc.contributor.author | Lemstra, Afina W. | - |
dc.contributor.author | van De Beek, Marleen | - |
dc.contributor.author | van der Flier, Wiesje | - |
dc.contributor.author | Barkhof, Frederik | - |
dc.contributor.author | Blanc, Frederik | - |
dc.contributor.author | Loureiro de Sousa, Paulo | - |
dc.contributor.author | Philippi, Nathalie | - |
dc.contributor.author | Cretin, Benjamin | - |
dc.contributor.author | Demuynck, Catherine | - |
dc.contributor.author | Nedelska, Zuzana | - |
dc.contributor.author | Hort, Jakub | - |
dc.contributor.author | Segura, Barbara | - |
dc.contributor.author | Junqué i Plaja, Carme, 1955- | - |
dc.contributor.author | Oppedal, Ketil | - |
dc.contributor.author | Aarsland, Dag | - |
dc.contributor.author | Westman, Eric | - |
dc.contributor.author | Kantarci, Kejal | - |
dc.contributor.author | Ferreira, Daniel | - |
dc.date.accessioned | 2023-07-26T09:12:56Z | - |
dc.date.available | 2023-07-26T09:12:56Z | - |
dc.date.issued | 2023-01-20 | - |
dc.identifier.issn | 2373-8057 | - |
dc.identifier.uri | http://hdl.handle.net/2445/201183 | - |
dc.description.abstract | Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We used data-driven analysis of magnetic resonance imaging (MRI) data to investigate DLB subtypes. We included 165 DLB from the Mayo Clinic and 3 centers from the European DLB consortium and performed a hierarchical cluster analysis to identify subtypes based on gray matter (GM) volumes. To characterize the subtypes, we used demographic and clinical data, as well as β-amyloid, tau, and cerebrovascular biomarkers at baseline, and cognitive decline over three years. We identified 3 subtypes: an older subtype with reduced cortical GM volumes, worse cognition, and faster cognitive decline (n = 49, 30%); a subtype with low GM volumes in fronto-occipital regions (n = 76, 46%); and a subtype of younger patients with the highest cortical GM volumes, proportionally lower GM volumes in basal ganglia and the highest frequency of cognitive fluctuations (n = 40, 24%). This study shows the existence of MRI subtypes in DLB, which may have implications for clinical workout, research, and therapeutic decisions. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41531-023-00448-6 | - |
dc.relation.ispartof | npj Parkinson's Disease, 2023, vol. 9, num. 1, p. 5 | - |
dc.relation.uri | https://doi.org/10.1038/s41531-023-00448-6 | - |
dc.rights | cc-by (c) Inguanzo, Anna et al., 2023 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malalties neurodegeneratives | - |
dc.subject.classification | Demència amb cossos de Lewy | - |
dc.subject.classification | Alfa-sinucleïna | - |
dc.subject.classification | Imatges per ressonància magnètica | - |
dc.subject.classification | Anàlisi de conglomerats | - |
dc.subject.other | Neurodegenerative Diseases | - |
dc.subject.other | Lewy body dementia | - |
dc.subject.other | Alpha-synuclein | - |
dc.subject.other | Magnetic resonance imaging | - |
dc.subject.other | Cluster analysis | - |
dc.title | MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 738103 | - |
dc.date.updated | 2023-07-26T09:12:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 36670121 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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738103.pdf | 1.03 MB | Adobe PDF | View/Open |
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