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http://hdl.handle.net/2445/201402
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DC Field | Value | Language |
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dc.contributor.author | Cucchiari, David | - |
dc.contributor.author | Egri, Natalia | - |
dc.contributor.author | Rodriguez Espinosa, Diana | - |
dc.contributor.author | Montagud Marrahi, Enrique | - |
dc.contributor.author | Casals Urquiza, Joaquim | - |
dc.contributor.author | Del Risco Zevallos, Jimena | - |
dc.contributor.author | Bodro, Marta | - |
dc.contributor.author | Ventura Aguiar, Pedro | - |
dc.contributor.author | Cofán Pujol, Federico | - |
dc.contributor.author | Cacho, Judit | - |
dc.contributor.author | Molina Andújar, Alícia | - |
dc.contributor.author | Rovira, Jordi | - |
dc.contributor.author | Banon Maneus, Elisenda | - |
dc.contributor.author | Ramírez Bajo, María José | - |
dc.contributor.author | Pérez Olmos, Anna | - |
dc.contributor.author | Garcia Pascual, Marta | - |
dc.contributor.author | Pascal i Capdevila, Mariona | - |
dc.contributor.author | Vilella i Morató, Anna | - |
dc.contributor.author | Trilla García, Antoni | - |
dc.contributor.author | Palou, Eduard | - |
dc.contributor.author | Revuelta, Ignacio | - |
dc.contributor.author | Juan, Manel | - |
dc.contributor.author | Campistol Plana, Josep M. | - |
dc.contributor.author | Oppenheimer Salinas, Federico | - |
dc.contributor.author | Moreno, Asunción | - |
dc.contributor.author | Miró Meda, José M. | - |
dc.contributor.author | Bayés, Beatriu | - |
dc.contributor.author | Diekmann, Fritz | - |
dc.date.accessioned | 2023-08-01T10:17:46Z | - |
dc.date.available | 2023-08-01T10:17:46Z | - |
dc.date.issued | 2022-10-07 | - |
dc.identifier.issn | 2373-8731 | - |
dc.identifier.uri | http://hdl.handle.net/2445/201402 | - |
dc.description.abstract | In kidney transplant recipients, there is discordance between the development of cellular and humoral response after vaccination against SARS-CoV-2. We sought to determine the interplay between the 2 arms of adaptive immunity in a 3-dose course of mRNA-1273 100 μg vaccine. Methods: Humoral (IgG/IgM) and cellular (N- and S-ELISpot) responses were studied in 117 kidney and 12 kidney-pancreas transplant recipients at the following time points: before the first dose, 14 d after the second dose' and before and after the third dose, with a median of 203 and 232 d after the start of the vaccination cycle, respectively. Results: After the second dose, 26.7% of naive cases experienced seroconversion. Before the third dose and in the absence of COVID-19, this percentage increased to 61.9%. After the third dose, seroconversion occurred in 80.0% of patients. Naive patients who had at any time point a detectable positivity for S-ELISpot were 75.2% of the population, whereas patients who maintained S-ELISpot positivity throughout the study were 34.3%. S-ELISpot positivity at 42 d was associated with final seroconversion (odds ratio' 3.14; 95% confidence interval' 1.10-8.96; P = 0.032). Final IgG titer was significantly higher in patients with constant S-ELISpot positivity (P < 0.001). Conclusions: A substantial proportion of kidney transplant recipients developed late seroconversion after 2 doses. Cellular immunity was associated with the development of a stronger humoral response | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wolters Kluwer Health | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1097/TXD.0000000000001389 | - |
dc.relation.ispartof | Transplantation Direct, 2022, vol. 8, num. 11, p. e1389 | - |
dc.relation.uri | https://doi.org/10.1097/TXD.0000000000001389 | - |
dc.rights | cc-by-nc-nd (c) Cucchiari, David et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Trasplantament renal | - |
dc.subject.classification | SARS-CoV-2 | - |
dc.subject.classification | Vacunes | - |
dc.subject.classification | RNA | - |
dc.subject.classification | Immunoglobulines | - |
dc.subject.classification | Resposta immunitària | - |
dc.subject.other | Kidney transplantation | - |
dc.subject.other | SARS-CoV-2 | - |
dc.subject.other | Vaccines | - |
dc.subject.other | RNA | - |
dc.subject.other | Immunoglobulins | - |
dc.subject.other | Immune response | - |
dc.title | Humoral and Cellular Immune Responses After a 3-dose Course of mRNA-1273 COVID-19 Vaccine in Kidney Transplant Recipients: A Prospective Cohort Study. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 729272 | - |
dc.date.updated | 2023-08-01T10:17:46Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9331341 | - |
dc.identifier.pmid | 36245998 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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File | Description | Size | Format | |
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729272.pdf | 1.9 MB | Adobe PDF | View/Open |
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