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https://hdl.handle.net/2445/201403
Títol: | Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status |
Autor: | Khoury, Nadine Martínez, María Ángeles Paz-Graniel I Martínez-González, Miguel Ángel, 1957- Corella Piquer, Dolores Castañer, Olga Martínez, J. Alfredo Alonso Gómez, Ángel M. Wärnberg, Julia Vioque, Jesús Romaguera, Dora López Miranda, José Estruch Riba, Ramon Tinahones, Francisco J. Lapetra, José Serra Majem, Lluís Bueno Cavanillas, Aurora Tur, Josep A. Cinza Sanjurjo, Sergio Pintó Sala, Xavier Gaforio, José J. Matía Martín, Pilar Vidal i Cortada, Josep Vázquez, Clotilde Daimiel, Lidia Ros Rahola, Emilio Sayon Orea, Carmen Sorlí, José V. Pérez Vega, Karla Alejandra García Ríos, Antonio Gómez Bellvert, Nuria Gómez Gracia, Enrique Zulet, M. Angeles Chaplin, Alice Casas Rodríguez, Rosa M. Salcedo Bellido, Inmaculada Tojal Sierra, Lucas Bernal López, M. Rosa Vázquez Ruiz, Zenaida Asensio, Eva M. Goday Arnó, Albert Peña Orihuela, Patricia J. Signes Pastor, Antonio J. Garcia-Arellano, Ana Fitó Colomer, Montserrat Babio, Nancy Salas Salvadó, Jordi |
Matèria: | Obesitat Teixit adipós Disruptors endocrins Dioxines Persones de mitjana edat Dieta Diet Obesity Adipose tissues Endocrine disrupting chemicals Dioxins Middle aged persons |
Data de publicació: | 25-març-2023 |
Publicat per: | Elsevier |
Resum: | Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods: In 5899 participants aged 55-75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results. Keywords: Abdominal obesity; Adiposity; Endocrine disrupting chemicals; Obesity; Polychlorinated dibenzo-p-furans (PCDD/F). |
Nota: | Reproducció del document publicat a: https://doi.org/10.1016/j.envres.2023.115697 |
És part de: | Environmental Research, 2023, vol. 227, p. 115697 |
URI: | https://hdl.handle.net/2445/201403 |
Recurs relacionat: | https://doi.org/10.1016/j.envres.2023.115697 |
ISSN: | 0013-9351 |
Apareix en les col·leccions: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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