Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/201403
Títol: Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status
Autor: Khoury, Nadine
Martínez, María Ángeles
Paz-Graniel I
Martínez-González, Miguel Ángel, 1957-
Corella Piquer, Dolores
Castañer, Olga
Martínez, J. Alfredo
Alonso Gómez, Ángel M.
Wärnberg, Julia
Vioque, Jesús
Romaguera, Dora
López Miranda, José
Estruch Riba, Ramon
Tinahones, Francisco J.
Lapetra, José
Serra Majem, Lluís
Bueno Cavanillas, Aurora
Tur, Josep A.
Cinza Sanjurjo, Sergio
Pintó Sala, Xavier
Gaforio, José J.
Matía Martín, Pilar
Vidal i Cortada, Josep
Vázquez, Clotilde
Daimiel, Lidia
Ros Rahola, Emilio
Sayon Orea, Carmen
Sorlí, José V.
Pérez Vega, Karla Alejandra
García Ríos, Antonio
Gómez Bellvert, Nuria
Gómez Gracia, Enrique
Zulet, M. Angeles
Chaplin, Alice
Casas Rodríguez, Rosa M.
Salcedo Bellido, Inmaculada
Tojal Sierra, Lucas
Bernal López, M. Rosa
Vázquez Ruiz, Zenaida
Asensio, Eva M.
Goday Arnó, Albert
Peña Orihuela, Patricia J.
Signes Pastor, Antonio J.
Garcia-Arellano, Ana
Fitó Colomer, Montserrat
Babio, Nancy
Salas Salvadó, Jordi
Matèria: Obesitat
Teixit adipós
Disruptors endocrins
Dioxines
Persones de mitjana edat
Dieta
Diet
Obesity
Adipose tissues
Endocrine disrupting chemicals
Dioxins
Middle aged persons
Data de publicació: 25-març-2023
Publicat per: Elsevier
Resum: Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods: In 5899 participants aged 55-75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results. Keywords: Abdominal obesity; Adiposity; Endocrine disrupting chemicals; Obesity; Polychlorinated dibenzo-p-furans (PCDD/F).
Nota: Reproducció del document publicat a: https://doi.org/10.1016/j.envres.2023.115697
És part de: Environmental Research, 2023, vol. 227, p. 115697
URI: https://hdl.handle.net/2445/201403
Recurs relacionat: https://doi.org/10.1016/j.envres.2023.115697
ISSN: 0013-9351
Apareix en les col·leccions:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Fitxers d'aquest document:
Fitxer Descripció DimensionsFormat 
733179.pdf981.4 kBAdobe PDFMostrar/Obrir


Aquest document està subjecte a una Llicència Creative Commons Creative Commons