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http://hdl.handle.net/2445/201424
Title: | Sex differences on multikinase inhibitors toxicity in patients with advanced gastroenteropancreatic neuroendocrine tumours |
Author: | Hernando, Jorge Roca Herrera, Maria García Álvarez, Alejandro Raymond, Eric Ruszniewski, Philippe Kulke, Matthew H. Grande, Enrique García Carbonero, Rocío Castellano, Daniel Salazar, Ramón Ibrahim, Toni Teulé Vega, Àlex Alonso, Vicente Fazio, Nicola Valle, Juan W. Tafuto, Salvatore Carmona, Ana Navarro, Victor Capdevila, Jaume |
Keywords: | Neuroendocrinologia Tumors Factors sexuals en les malalties Neuroendocrinology Tumors Sex factors in disease |
Issue Date: | 1-Jul-2023 |
Publisher: | Elsevier BV |
Abstract: | Purpose: There is an increasing interest in the role of sex and gender in cancer pa-tients. The impact of sex differences in oncological systemic therapies is still unknown, and there is a lack of evidence specially in uncommon neoplasms like neuroendocrine tumours (NET). In the present study, we combine the differential toxicities by sex in five published clinical trials with multikinase inhibitors (MKI) in gastroenteropancreatic (GEP) NET.Methods: We performed a pooled univariate analysis of reported toxicity in patients treated in five phase 2 and phase 3 clinical trials with MKI in the GEP NET setting: sunitinib (SU11248, SUN1111), Pazopanib (PAZONET), sorafenib-bevacizumab (GETNE0801) and Lenvatinib (TALENT). Differential toxicities between male and female patients were evaluated considering relationship with study drug and different weights of each trial by random effect adjustment.Results: We found nine toxicities which were more frequent in female patients (leukopenia, alopecia, vomiting, headache, bleeding, nausea, dysgeusia, neutrophil count decreased and dry mouth) and two toxicities being more frequent in male patients (Anal Symptoms and Insomnia). Asthenia and diarrhoea were the only severe (Grade 3-4) toxicities more frequent in female pa-tients.Conclusions: Sex-related differences in toxicity with the MKI treatment require targeted in-formation and individualised management of patients with NET. Differential reporting of toxicity should be promoted when clinical trials are published.(c) 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY -NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.ejca.2023.04.013 |
It is part of: | European Journal of Cancer, 2023, vol. 188, p. 39-48 |
URI: | http://hdl.handle.net/2445/201424 |
Related resource: | https://doi.org/10.1016/j.ejca.2023.04.013 |
ISSN: | 0959-8049 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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PIIS0959804923001995.pdf | 2.27 MB | Adobe PDF | View/Open |
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