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Title: | Prognostic Impact of Nutritional Status After Transcatheter Edge-to-Edge Mitral Valve Repair: The MIVNUT Registry |
Author: | Caneiro Queija, Berenice Raposeiras Roubín, Sergio Adamo, Marianna Freixa, Xavier Arzamendi, Dabit Benito González, Tomas Montefusco, Antonio Pascual, Isaac Nombela Franco, Luis Rodés Cabau, Josep Shuvy, Mony Portolés Hernández, Antonio Godino, Cosmo Haberman, Dan Lupi, Laura Regueiro, Ander Hion Li, Chin Fernández Vázquez , Felipe Frea, Simone Avanzas, Pablo Tirado Conte, Gabriela Paradis, Jean Michel Peretz, Alona Moñivas, Vanessa Baz, Jose A. Galasso, Michele Branca, Luca Sanchís, Laura Asmarats, Lluís Garrote Coloma, Carmen Angelini, Filippo León, Victor Agustin, José A. de Alperi, Alberto Beeri, Ronen Maccagni, Gloria Sabaté, Manel Fernández Peregrina, Estefanía Gualis, Javier Bocchino, Pier Paolo Curello, Salvatore Íñiguez Romo, Andrés Estévez Loureiro, Rodrigo |
Keywords: | Malnutrició Insuficiència cardíaca Mortalitat Malnutrition Heart failure Mortality |
Issue Date: | 18-Oct-2022 |
Publisher: | AHA Journals |
Abstract: | Background Malnutrition is associated with poor prognosis in several cardiovascular diseases. However, its prognostic impact in patients undergoing transcatheter edge-to-edge mitral valve repair (TEER) is not well known. This study sought to assess the prevalence, clinical associations, and prognostic consequences of malnutrition in patients undergoing TEER. Methods and Results A total of 892 patients undergoing TEER from the international MIVNUT (Mitral Valve Repair and Nutritional Status) registry were studied. Malnutrition status was assessed with the Controlling Nutritional Status score. The association of nutritional status with mortality was analyzed with multivariable Cox regression models, whereas the association with heart failure admission was assessed by Fine-Gray models, with death as a competing risk. According to the Controlling Nutritional Status score, 74.4% of patients with TEER had any degree of malnutrition at the time of TEER (75.1% in patients with body mass index <25?kg/m2, 72.1% in those with body mass index ?25?kg/m2). However, only 20% had moderate-severe malnutrition. TEER was successful in most of patients (94.2%). During a median follow-up of 1.6?years (interquartile range, 0.6-3.0), 267 (29.9%) patients died and 256 patients (28.7%) were admitted for heart failure after TEER. Compared with normal nutritional status moderate-severe malnutrition resulted a strong predictor of mortality (adjusted hazard ratio [HR], 2.1 [95% CI, 1.1-2.4]; P<0.001) and heart failure admission (adjusted subdistribution HR, 1.6 [95% CI, 1.1-2.4]; P=0.015). Conclusions Malnutrition is common among patients submitted to TEER, and moderate-severe malnutrition is strongly associated with increased mortality and heart failure readmission. Assessment of nutritional status in these patients may help to improve risk stratification. |
Note: | Reproducció del document publicat a: https://doi.org/10.1161/jaha.121.023121 |
It is part of: | Journal of The American Heart Association, 2022, vol. 11, num. 20, p. e023121 |
URI: | http://hdl.handle.net/2445/201460 |
Related resource: | https://doi.org/10.1161/jaha.121.023121 |
ISSN: | 2047-9980 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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File | Description | Size | Format | |
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Prognostic Impact of Nutritional Status After_AmericanHeartAsso.pdf | 2.53 MB | Adobe PDF | View/Open |
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