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Title: | Trends in the Prescription of Strong Opioids for Chronic Non-Cancer Pain in Primary Care in Catalonia: Opicat-Padris-Project |
Author: | Perelló Bratescu, Aina Dürsteler, Christian Álvarez Carrera, Maria Asunción Granés, Laura Kostov, Belchin Sisó Almirall, Antoni |
Keywords: | Opiacis Avaluació del risc per la salut Tractament del dolor Opioids Health risk assessment Pain treatment |
Issue Date: | 20-Jan-2022 |
Publisher: | MDPI |
Abstract: | In chronic non-cancer pain (CNCP), evidence of the effectiveness of strong opioids (SO) is very limited. Despite this, their use is increasingly common. To examine SO prescriptions, we designed a descriptive, longitudinal, retrospective population-based study, including patients aged >= 15 years prescribed SO for >= 3 months continuously in 2013-2017 for CNCP in primary care in Catalonia. Of the 22,691 patients included, 17,509 (77.2%) were women, 10,585 (46.6%) were aged >80 years, and most had incomes of <euro18,000 per year. The most common diagnoses were musculoskeletal diseases and psychiatric disorders. There was a predominance of transdermal fentanyl in the defined daily dose (DDD) per thousand inhabitants/day, with the greatest increase for tapentadol (312% increase). There was an increase of 66.89% in total DDD per thousand inhabitants/day for SO between 2013 (0.737) and 2017 (1.230). The mean daily oral morphine equivalent dose/day dispensed for all drugs was 83.09 mg. Transdermal fentanyl and immediate transmucosal release were the largest cost components. In conclusion, there was a sustained increase in the prescription of SO for CNCP, at high doses, and in mainly elderly patients, predominantly low-income women. The new SO are displacing other drugs. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/pharmaceutics14020237 |
It is part of: | Pharmaceutics, 2022, vol. 14, num. 2, p. 237 |
URI: | http://hdl.handle.net/2445/201469 |
Related resource: | https://doi.org/10.3390/pharmaceutics14020237 |
ISSN: | 1999-4923 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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