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DC Field | Value | Language |
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dc.contributor.author | Farré Ventura, Ramon | - |
dc.contributor.author | Almendros López, Isaac | - |
dc.contributor.author | Martínez García, Miguel Ángel | - |
dc.contributor.author | Gozal, David | - |
dc.date.accessioned | 2023-08-28T10:40:58Z | - |
dc.date.available | 2023-08-28T10:40:58Z | - |
dc.date.issued | 2022-11-20 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/2445/201580 | - |
dc.description.abstract | Sleep apnea (SA) is a very prevalent sleep breathing disorder mainly characterized by intermittent hypoxemia and sleep fragmentation, with ensuing systemic inflammation, oxidative stress, and immune deregulation. These perturbations promote the risk of end-organ morbidity, such that SA patients are at increased risk of cardiovascular, neurocognitive, metabolic and malignant disorders. Investigating the potential mechanisms underlying SA-induced end-organ dysfunction requires the use of comprehensive experimental models at the cell, animal and human levels. This review is primarily focused on the experimental models employed to date in the study of the consequences of SA and tackles 3 different approaches. First, cell culture systems whereby controlled patterns of intermittent hypoxia cycling fast enough to mimic the rates of episodic hypoxemia experienced by patients with SA. Second, animal models consisting of implementing realistic upper airway obstruction patterns, intermittent hypoxia, or sleep fragmentation such as to reproduce the noxious events characterizing SA. Finally, human SA models, which consist either in subjecting healthy volunteers to intermittent hypoxia or sleep fragmentation, or alternatively applying oxygen supplementation or temporary nasal pressure therapy withdrawal to SA patients. The advantages, limitations, and potential improvements of these models along with some of their pertinent findings are reviewed. | - |
dc.format.extent | 24 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/ijms232214430 | - |
dc.relation.ispartof | International Journal of Molecular Sciences, 2022, vol. 23, num. 22, p. 14430 | - |
dc.relation.uri | https://doi.org/10.3390/ijms232214430 | - |
dc.rights | cc-by (c) Farré Ventura, Ramon et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Síndromes d'apnea del son | - |
dc.subject.classification | Trastorns del son | - |
dc.subject.classification | Fisiologia del son | - |
dc.subject.classification | Models animals en la investigació | - |
dc.subject.classification | Factors de risc en les malalties | - |
dc.subject.other | Sleep apnea syndromes | - |
dc.subject.other | Sleep disorders | - |
dc.subject.other | Sleep physiology | - |
dc.subject.other | Animal models in research | - |
dc.subject.other | Risk factors in diseases | - |
dc.title | Experimental Models to Study End-Organ Morbidity in Sleep Apnea: Lessons Learned and Future Directions. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 729198 | - |
dc.date.updated | 2023-08-28T10:40:58Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9333062 | - |
dc.identifier.pmid | 36430904 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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729198.pdf | 3.89 MB | Adobe PDF | View/Open |
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