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http://hdl.handle.net/2445/201623
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DC Field | Value | Language |
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dc.contributor.author | Lledó, Gema | - |
dc.contributor.author | Xipell, Marc | - |
dc.contributor.author | Ferreira Gomes, Manuel | - |
dc.contributor.author | Solé, Manel | - |
dc.contributor.author | Garcia Herrera, Adriana | - |
dc.contributor.author | Cervera i Segura, Ricard, 1960- | - |
dc.contributor.author | Quintana Porras, Luis F. | - |
dc.contributor.author | Espinosa, Gerard | - |
dc.date.accessioned | 2023-08-30T08:00:34Z | - |
dc.date.available | 2023-08-30T08:00:34Z | - |
dc.date.issued | 2022-06-22 | - |
dc.identifier.issn | 2048-8505 | - |
dc.identifier.uri | http://hdl.handle.net/2445/201623 | - |
dc.description.abstract | The role of repeat kidney biopsy in lupus nephritis (LN) with renal remission is unclear. The aim of this study was to assess this role in a real-life scenario. This retrospective, single-centre study included 56 patients with LN diagnosed from 1998 to 2019, with an initial kidney biopsy (KB1) at the onset of LN and a second kidney biopsy (KB2) after achieving renal remission. A total of 51 (91.1%) patients were women with a median age of 29.9 years [interquartile range (IQR) 23.4-40.6] at the time of LN diagnosis. KB2s were performed after 41.1 months (IQR 30.1-52.5) of KB1. At the time of KB2, complete renal response was achieved in 51 (91.1%) patients. The median activity index decreased from a baseline value of 6.5 (IQR 2.8-11) to 0 (IQR 0-2) (P < .001). The chronicity index worsened from 1 (IQR 0-2) to 2 (IQR 1-3) (P = .01). In patients with proliferative/mixed forms at KB2, the chronicity index median value increased to 3 (IQR 1.5-4), as well as interstitial fibrosis and tubular atrophy [Formula: see text]25%, from 5.4% to 13.5%. Persistent histological active LN (activity index ≥2) was present in 11 (19.6%) KB2s. There were no differences when comparing immunological parameters between both groups (activity index ≥2 versus <2) at KB2, nor in the percentage of patients who presented renal flare. Immunosuppressive treatment was withdrawn in 35 (62.5%) patients and maintained/switched in 21 (37.5%). Afterward, new renal flare occurred in 9 patients per group (25.7% and 43%, respectively), after a median time of 39 months (IQR 6.5-55) and 7 months (IQR 6-30), respectively. There was no difference in the number of patients who developed chronic kidney disease [n = 14 (25%)] according to the treatment. In conclusion, KB2 provides valuable information to guide immunosuppressive maintenance therapy. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/ckj/sfac150 | - |
dc.relation.ispartof | Clinical Kidney Journal, 2022, vol. 15, num. 11, p. 2081-2088 | - |
dc.relation.uri | https://doi.org/10.1093/ckj/sfac150 | - |
dc.relation.uri | https://doi.org/10.1093/ckj/sfad038 | correction |
dc.rights | cc-by-nc (c) Lledó, Gema et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malalties del ronyó | - |
dc.subject.classification | Malalties autoimmunitàries | - |
dc.subject.classification | Lupus | - |
dc.subject.classification | Biòpsia | - |
dc.subject.classification | Immunosupressió | - |
dc.subject.other | Kidney diseases | - |
dc.subject.other | Autoimmune diseases | - |
dc.subject.other | Lupus | - |
dc.subject.other | Biopsy | - |
dc.subject.other | Immunosuppression | - |
dc.title | Kidney biopsy in lupus nephritis after achieving clinical renal remission: paving the way for renal outcome assessment. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 731019 | - |
dc.date.updated | 2023-08-30T08:00:34Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9329721 | - |
dc.identifier.pmid | 36325009 | original |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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original article.pdf | 1.19 MB | Adobe PDF | View/Open | |
correction.pdf | 95.51 kB | Adobe PDF | View/Open |
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