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http://hdl.handle.net/2445/201727
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DC Field | Value | Language |
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dc.contributor.author | Rogers, Miranda | - |
dc.contributor.author | Gill, Dipender | - |
dc.contributor.author | Ahlqvist, Emma | - |
dc.contributor.author | Robinson, Timothy M. | - |
dc.contributor.author | Mariosa, Daniela | - |
dc.contributor.author | Johansson, Mattias | - |
dc.contributor.author | Cortez Cardoso Penha, Ricardo | - |
dc.contributor.author | Dossus, Laure | - |
dc.contributor.author | Gunter, Marc J. | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.contributor.author | Davey Smith, George | - |
dc.contributor.author | Martin, Richard M. | - |
dc.contributor.author | Yarmolinsky, James | - |
dc.date.accessioned | 2023-09-04T15:36:18Z | - |
dc.date.available | 2023-09-04T15:36:18Z | - |
dc.date.issued | 2023-06-01 | - |
dc.identifier.issn | 2589-0042 | - |
dc.identifier.uri | http://hdl.handle.net/2445/201727 | - |
dc.description.abstract | Preclinical and genetic studies suggest that impaired glucose-dependent insulino-tropic polypeptide receptor (GIPR) signaling worsens glycemic control. The rela-tionship between GIPR signaling and the risk of cancers influenced by impaired glucose homeostasis is unclear. We examined the association of a variant in GIPR, rs1800437 (E354Q), shown to impair long-term GIPR signaling and lower circulating glucose-dependent insulinotropic peptide concentrations, with risk of 6 cancers influenced by impaired glucose homeostasis (breast, colorectal, endometrial, lung, pancreatic, and renal) in up to 235,698 cases and 333,932 con-trols. Each copy of E354Q was associated with a higher risk of overall and luminal A-like breast cancer and this association was consistent in replication and colocal-ization analyses. E354Q was also associated with higher postprandial glucose concentrations but diminished insulin secretion and lower testosterone concen-trations. Our human genetics analysis suggests an adverse effect of the GIPR E354Q variant on breast cancer risk, supporting further evaluation of GIPR signaling in breast cancer prevention. | - |
dc.format.extent | 19 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.isci.2023.106848 | - |
dc.relation.ispartof | iScience, 2023, vol. 26, num. 6 | - |
dc.relation.uri | https://doi.org/10.1016/j.isci.2023.106848 | - |
dc.rights | cc by (c) Rogers, Miranda et al, 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Genètica mèdica | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Medical genetics | - |
dc.subject.other | Cancer | - |
dc.title | Genetically proxied impaired GIPR signaling and risk of 6 cancers | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-08-18T09:22:45Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 37250804 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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PIIS2589004223009252.pdf | 3.11 MB | Adobe PDF | View/Open |
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