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http://hdl.handle.net/2445/201871
Title: | Understanding the neurological implications of acute and long COVID using brain organoids |
Author: | García González, Laura Martí Sarrias, Andrea Puertas Castro, Ma. Carmen Bayón Gil, Ángel Resa Infante, Patricia Martínez Picado, Francisco Javier Navarro, Arcadi Acosta, Sandra |
Keywords: | COVID-19 Manifestacions neurològiques de les malalties COVID-19 Neurologic manifestations of general diseases |
Issue Date: | 17-Jul-2023 |
Publisher: | The Company of Biologists |
Abstract: | As early as in the acute phase of the coronavirus disease 2019 about the long-term implications of infection. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like many other viruses, can trigger chronic disorders that last months or even years. Long COVID, the chronic and persistent disorder lasting more than 12 weeks after the primary infection with SARS-CoV-2, involves a variable number of neurological manifestations, ranging from mild to severe and even fatal. In vitro and in vivo modeling suggest that SARS-CoV-2 infection drives changes within neurons, glia and the brain vasculature. In this Review, we summarize the current understanding of the neuropathology of acute and long COVID, with particular emphasis on the knowledge derived from brain organoid models. We highlight the advantages and main limitations of brain organoids, leveraging their humanoerived origin, their similarity in cellular and tissue architecture to human tissues, and their potential to decipher the pathophysiology of long COVID. |
Note: | Reproducció del document publicat a: https://doi.org/10.1242/dmm.050049 |
It is part of: | Disease Models & Mechanisms, 2023, vol. 16, num. 7, p. dmm050049 |
URI: | http://hdl.handle.net/2445/201871 |
Related resource: | https://doi.org/10.1242/dmm.050049 |
ISSN: | 1754-8411 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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