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http://hdl.handle.net/2445/201920
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DC Field | Value | Language |
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dc.contributor.author | Eills, James | - |
dc.contributor.author | Picazo Frutos, Román | - |
dc.contributor.author | Burueva, Dudari B. | - |
dc.contributor.author | Kovtunova, Larisa M. | - |
dc.contributor.author | Azagra, Marc | - |
dc.contributor.author | Marco Rius, Irene | - |
dc.contributor.author | Budker, Dmitry | - |
dc.contributor.author | Koptyug, Igor V. | - |
dc.date.accessioned | 2023-09-13T10:41:49Z | - |
dc.date.available | 2023-09-13T10:41:49Z | - |
dc.date.issued | 2023-07-14 | - |
dc.identifier.issn | 2050-5620 | - |
dc.identifier.uri | http://hdl.handle.net/2445/201920 | - |
dc.description.abstract | We show that catalyst-free aqueous solutions of hyperpolarized [1-13C]succinate can be produced using parahydrogen-induced polarization (PHIP) and a combination of homogeneous and heterogeneous catalytic hydrogenation reactions. We generate hyperpolarized [1-13C]fumarate via PHIP using para-enriched hydrogen gas with a homogeneous ruthenium catalyst, and subsequently remove the toxic catalyst and reaction side products via a purification procedure. Following this, we perform a second hydrogenation reaction using normal hydrogen gas to convert the fumarate into succinate using a solid Pd/Al2O3 catalyst. This inexpensive polarization protocol has a turnover time of a few minutes, and represents a major advance for in vivo applications of [1-13C]succinate as a hyperpolarized contrast agent. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Royal Society of Chemistry | - |
dc.relation.isformatof | https://doi.org/10.1039/d3cc01803b | - |
dc.relation.ispartof | Chemical Communications, 2023, vol. 59, num. 62, p. 9509-9512 | - |
dc.relation.uri | https://doi.org/10.1039/d3cc01803b | - |
dc.rights | cc by-nc (c) Eills, James et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) | - |
dc.subject.classification | Hidrogenació | - |
dc.subject.classification | Processos químics | - |
dc.subject.other | Hydrogenation | - |
dc.subject.other | Chemical processes | - |
dc.title | Combined homogeneous and heterogeneous hydrogenation to yield catalyst-free solutions of parahydrogen-hyperpolarized [1-13C]succinate | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-09-06T06:39:36Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 6601964 | - |
dc.identifier.pmid | 37450281 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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2023_CheCom_Combined_EillsJ.pdf | 850.8 kB | Adobe PDF | View/Open |
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