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http://hdl.handle.net/2445/202098
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DC Field | Value | Language |
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dc.contributor.author | Alcaraz Asensio, Antonio | - |
dc.contributor.author | Gacci, Mauro | - |
dc.contributor.author | Ficarra, Vincenzo | - |
dc.contributor.author | Medina Polo, José | - |
dc.contributor.author | Salonia, Andrea | - |
dc.contributor.author | Fernández Gómez, Jesús M. | - |
dc.contributor.author | Ciudin, Alexandru | - |
dc.contributor.author | Castro Diaz, David | - |
dc.contributor.author | Rodríguez Antolín, Alfredo | - |
dc.contributor.author | Carballido Rodríguez, Joaquín | - |
dc.contributor.author | Cózar Olmo, José M. | - |
dc.contributor.author | BúcarTerrades, Santiago | - |
dc.contributor.author | Pérez León, Noemí | - |
dc.contributor.author | Brenes Bermúdez, Francisco J. | - |
dc.contributor.author | Molero García, José M. | - |
dc.contributor.author | Fernández-Pro Ledesma, Antonio | - |
dc.contributor.author | Herdman, Michael | - |
dc.contributor.author | Manasanch, José | - |
dc.contributor.author | Angulo, Javier C. | - |
dc.contributor.author | QUALIPROST Study Group | - |
dc.date.accessioned | 2023-09-21T13:31:42Z | - |
dc.date.available | 2023-09-21T13:31:42Z | - |
dc.date.issued | 2022-02-12 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/2445/202098 | - |
dc.description.abstract | We investigated changes in symptoms and quality of life (QoL) in men with moderate-to-severe lower urinary tract symptoms associated with benign prostatic hyperplasia (LUTS/BPH) receiving the hexanic extract of Serenoa repens (HESr) and compared results with a matched group on watchful waiting (WW). Data was from a real-world, open-label, prospective, multicenter study. This sub-group analysis included patients with moderate-to-severe symptoms receiving either the HESr 320 mg/daily for six months (HESr) or who remained untreated for LUTS/BPH (WW). Changes in urinary symptoms and QoL were measured by IPSS and BII questionnaires. Two statistical approaches (iterative matching and propensity score pairing) were used to maximize between-group comparability at baseline. Tolerability was assessed in the HESr group. After iterative matching, data for analysis was available for 783 patients (102 WW, 681 HESr). IPSS scores improved by a mean (SD) of 3.8 (4.4) points in the HESr group and by 2.2 (4.5) points in the WW group (p = 0.002). Changes in BII score were 1.8 (2.4) points and 1.0 (2.2) points, respectively (p < 0.001). Three patients (0.9%) treated with the HESr reported mild adverse effects. Moderate-severe LUTS/BPH patients treated for six months with the HESr showed greater improvements in symptoms and QoL than matched patients on WW, with a very low rate of adverse effects. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm11040967 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2022, vol. 11, num. 4, p. 967 | - |
dc.relation.uri | https://doi.org/10.3390/jcm11040967 | - |
dc.rights | cc by (c) Alcaraz Asensio, Antonio et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Qualitat de vida | - |
dc.subject.classification | Homes | - |
dc.subject.classification | Malalties de l'aparell urinari | - |
dc.subject.other | Quality of life | - |
dc.subject.other | Men | - |
dc.subject.other | Diseases of the urinary organs | - |
dc.title | Efficacy and Safety of the Hexanic Extract of Serenoa repens vs. Watchful Waiting in Men with Moderate to Severe LUTS-BPH: Results of a Paired Matched Clinical Study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-07-04T07:56:11Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9299306 | - |
dc.identifier.pmid | 35207238 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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File | Description | Size | Format | |
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Efficacy and Safety of the Hexanic Extract of Serenoa repens vs. Watchful Waiting in Men_ClincalMedicine.pdf | 776.23 kB | Adobe PDF | View/Open |
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