Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/202160
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Montagud Marrahi, Enrique | - |
dc.contributor.author | Cuadrado Payán, Elena | - |
dc.contributor.author | Hermida, Evelyn | - |
dc.contributor.author | Cacho, Judit | - |
dc.contributor.author | Cucchiari, David | - |
dc.contributor.author | Revuelta, Ignacio | - |
dc.contributor.author | Del Risco Zevallos, Jimena | - |
dc.contributor.author | Esforzado Armengol, Nuria | - |
dc.contributor.author | Cofán Pujol, Federico | - |
dc.contributor.author | Oppenheimer Salinas, Federico | - |
dc.contributor.author | Torregrosa Prats, José Vicente | - |
dc.contributor.author | Ferrer Fábrega, Joana | - |
dc.contributor.author | Amor, Antonio | - |
dc.contributor.author | Esmatjes Mompó, Enric | - |
dc.contributor.author | Ramírez Bajo, María José | - |
dc.contributor.author | Musquera i Felip, Mireia | - |
dc.contributor.author | Cooper, Mathew | - |
dc.contributor.author | Bayés Genís, Beatriu | - |
dc.contributor.author | Campistol Plana, Josep M. | - |
dc.contributor.author | Diekmann, Fritz | - |
dc.contributor.author | Ventura Aguiar, Pedro | - |
dc.date.accessioned | 2023-09-21T13:41:12Z | - |
dc.date.available | 2023-09-21T13:41:12Z | - |
dc.date.issued | 2022-05-27 | - |
dc.identifier.issn | 0085-2538 | - |
dc.identifier.other | 35644282 | - |
dc.identifier.uri | http://hdl.handle.net/2445/202160 | - |
dc.description.abstract | Several organ allocation protocols give priority to wait-listed simultaneous kidney-pancreas (SPK) transplant recipients to mitigate the higher cardiovascular risk of patients with diabetes mellitus on dialysis. The available information regarding the impact of preemptive simultaneous kidney-pancreas transplantation on recipient and graft outcomes is nonetheless controversial. To help resolve this, we explored the influence of preemptive simultaneous kidney-pancreas transplants on patient and graft survival through a retrospective analysis of the OPTN/UNOS database, encompassing 9690 simultaneous transplant recipients between 2000 and 2017. Statistical analysis was performed applying a propensity score analysis to minimize bias. Of these patients, 1796 (19%) were transplanted preemptively. At ten years, recipient survival was significantly superior in the preemptive group when compared to the non-preemptive group (78.9% vs 71.8%). Dialysis at simultaneous kidney-pancreas transplantation was an independent significant risk for patient survival (hazard ratio 1.66 [95% confidence interval 1.32-2.09]), especially if the dialysis duration was 12 months or longer. Preemptive transplantation was also associated with significant superior kidney graft survival compared to those on dialysis (death-censored: 84.3% vs 75.4%, respectively; estimated half-life of 38.57 [38.33 -38.81] vs 22.35 [22.17 - 22.53] years, respectively). No differences were observed between both groups neither for pancreas graft survival nor for post-transplant surgical complications. Thus, our results sustain the relevance of early referral for pancreas transplantation and the importance of pancreas allocation priority in reducing patient mortality after simultaneous kidney-pancreas transplantation. | - |
dc.format.extent | 50 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.kint.2022.04.032 | - |
dc.relation.ispartof | Kidney International, 2022, vol. 102, num. 2, p. 421-430 | - |
dc.relation.uri | https://doi.org/10.1016/j.kint.2022.04.032 | - |
dc.rights | cc-by-nc-nd (c) International Society of Nephrology, 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Trasplantament renal | - |
dc.subject.classification | Diàlisi | - |
dc.subject.other | Kidney transplantation | - |
dc.subject.other | Dialysis | - |
dc.title | Preemptive simultaneous pancreas kidney transplantation has survival benefit to patients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 730457 | - |
dc.date.updated | 2023-09-21T13:41:12Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9315681 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
730457.pdf | 2.12 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License