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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/202167
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dc.contributor.authorTarifa, Carmen-
dc.contributor.authorVallmitjana, Alexander-
dc.contributor.authorJiménez Sábado, Verónica-
dc.contributor.authorMarchena, Miquel-
dc.contributor.authorLlach, Anna-
dc.contributor.authorHerraiz Martínez, Adela-
dc.contributor.authorGodoy-Marín, Héctor-
dc.contributor.authorNolla-Colomer, Carme-
dc.contributor.authorGinel, Antonino-
dc.contributor.authorViñolas, Xavier-
dc.contributor.authorMontiel, José-
dc.contributor.authorCiruela Alférez, Francisco-
dc.contributor.authorEchebarria, Blas-
dc.contributor.authorBenitez, Raúl-
dc.contributor.authorCinca, Juan-
dc.contributor.authorHove-Madsen, Leif-
dc.date.accessioned2023-09-21T17:07:39Z-
dc.date.available2023-09-21T17:07:39Z-
dc.date.issued2023-02-01-
dc.identifier.issn2452-302X-
dc.identifier.urihttp://hdl.handle.net/2445/202167-
dc.description.abstractAnalysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical modeling, incorporating modulation of RyR2 gating, showed that only the observed combinations of RyR2 phosphorylation and calsequestrin-2 levels can account for the spatio-temporal distribution of sparks in patients with and without AF. Furthermore, we demonstrate that preferential calcium release near the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in atrial myocytes from patients with AF-
dc.format.extent15 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.jacbts.2022.07.013-
dc.relation.ispartofJACC: Basic to Translational Science, 2023, vol. 8, num. 1, p. 1-15-
dc.relation.urihttps://doi.org/10.1016/j.jacbts.2022.07.013-
dc.rightscc-by (c) Tarifa, Carmen et al., 2023-
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.sourceArticles publicats en revistes (Patologia i Terapèutica Experimental)-
dc.subject.classificationFibril·lació auricular-
dc.subject.classificationCèl·lules musculars-
dc.subject.classificationCanals de calci-
dc.subject.otherAtrial fibrillation-
dc.subject.otherMuscle cells-
dc.subject.otherCalcium channels-
dc.titleSpatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec732318-
dc.date.updated2023-09-21T17:07:39Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid36777175-
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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