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http://hdl.handle.net/2445/202167
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DC Field | Value | Language |
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dc.contributor.author | Tarifa, Carmen | - |
dc.contributor.author | Vallmitjana, Alexander | - |
dc.contributor.author | Jiménez Sábado, Verónica | - |
dc.contributor.author | Marchena, Miquel | - |
dc.contributor.author | Llach, Anna | - |
dc.contributor.author | Herraiz Martínez, Adela | - |
dc.contributor.author | Godoy-Marín, Héctor | - |
dc.contributor.author | Nolla-Colomer, Carme | - |
dc.contributor.author | Ginel, Antonino | - |
dc.contributor.author | Viñolas, Xavier | - |
dc.contributor.author | Montiel, José | - |
dc.contributor.author | Ciruela Alférez, Francisco | - |
dc.contributor.author | Echebarria, Blas | - |
dc.contributor.author | Benitez, Raúl | - |
dc.contributor.author | Cinca, Juan | - |
dc.contributor.author | Hove-Madsen, Leif | - |
dc.date.accessioned | 2023-09-21T17:07:39Z | - |
dc.date.available | 2023-09-21T17:07:39Z | - |
dc.date.issued | 2023-02-01 | - |
dc.identifier.issn | 2452-302X | - |
dc.identifier.uri | http://hdl.handle.net/2445/202167 | - |
dc.description.abstract | Analysis of the spatio-temporal distribution of calcium sparks showed a preferential increase in sparks near the sarcolemma in atrial myocytes from patients with atrial fibrillation (AF), linked to higher ryanodine receptor (RyR2) phosphorylation at s2808 and lower calsequestrin-2 levels. Mathematical modeling, incorporating modulation of RyR2 gating, showed that only the observed combinations of RyR2 phosphorylation and calsequestrin-2 levels can account for the spatio-temporal distribution of sparks in patients with and without AF. Furthermore, we demonstrate that preferential calcium release near the sarcolemma is key to a higher incidence and amplitude of afterdepolarizations in atrial myocytes from patients with AF | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.jacbts.2022.07.013 | - |
dc.relation.ispartof | JACC: Basic to Translational Science, 2023, vol. 8, num. 1, p. 1-15 | - |
dc.relation.uri | https://doi.org/10.1016/j.jacbts.2022.07.013 | - |
dc.rights | cc-by (c) Tarifa, Carmen et al., 2023 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Fibril·lació auricular | - |
dc.subject.classification | Cèl·lules musculars | - |
dc.subject.classification | Canals de calci | - |
dc.subject.other | Atrial fibrillation | - |
dc.subject.other | Muscle cells | - |
dc.subject.other | Calcium channels | - |
dc.title | Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 732318 | - |
dc.date.updated | 2023-09-21T17:07:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 36777175 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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732318.pdf | 3.41 MB | Adobe PDF | View/Open |
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