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Title: Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)
Author: Palomar Cros, Anna
Straif, Kurt
Romaguera, Dora
Aragonés, Nuria
Castaño Vinyals, Gemma
Martín, Vicente
Moreno Aguado, Víctor
Gómez Acebo, Inés
Guevara, Marcela
Aizpurua, Amaia
Molina Barceló, Ana
Jiménez Moleón, José Juan
Tardón, Adonina
Contreras Llanes, Manuel
Marcos Gragera, Rafael
Huerta Castaño, José María
Pérez Gómez, Beatriz
Espinosa, Ana
Hernández Segura, Natalia
Obón Santacana, Mireia
Alonso Molero, Jessica
Burgui, Rosana
Amiano, Pilar
Pinto Carbó, Marina
Olmedo Requena, Rocío
Fernández Tardón, Guillermo
Santos Sánchez, Vanessa
Fernández de Larrea Baz, Nerea
Fernández Villa, Tania
Casabonne, Delphine
Dierssen Sotos, Trinidad
Ardanaz, Eva
Dorronsoro, Ane
Pollán, Marina
Kogevinas, Manolis
Lassale, Camille
Keywords: Edulcorants sintètics
Nonnutritive sweetener
Issue Date: 16-Jun-2023
Publisher: Wiley
Abstract: Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (<greater than or equal to> third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR=1.58, 95% CI 1.05-2.41, P trend=.03) and stomach cancer (OR=2.27 [0.99-5.44], P trend=.06). High consumption of aspartame, was associated with stomach cancer (OR=2.04 [0.7-5.4], P trend=.05), while a lower risk was observed for breast cancer (OR=0.28 [0.08-0.83], P trend=.03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.
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It is part of: International Journal of Cancer, 2023, vol. 153, num. 5, p. 979-993
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ISSN: 1097-0215
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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