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http://hdl.handle.net/2445/202622
Title: | Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain) |
Author: | Palomar Cros, Anna Straif, Kurt Romaguera, Dora Aragonés, Nuria Castaño Vinyals, Gemma Martín, Vicente Moreno Aguado, Víctor Gómez Acebo, Inés Guevara, Marcela Aizpurua, Amaia Molina Barceló, Ana Jiménez Moleón, José Juan Tardón, Adonina Contreras Llanes, Manuel Marcos Gragera, Rafael Huerta Castaño, José María Pérez Gómez, Beatriz Espinosa, Ana Hernández Segura, Natalia Obón Santacana, Mireia Alonso Molero, Jessica Burgui, Rosana Amiano, Pilar Pinto Carbó, Marina Olmedo Requena, Rocío Fernández Tardón, Guillermo Santos Sánchez, Vanessa Fernández de Larrea Baz, Nerea Fernández Villa, Tania Casabonne, Delphine Dierssen Sotos, Trinidad Ardanaz, Eva Dorronsoro, Ane Pollán, Marina Kogevinas, Manolis Lassale, Camille |
Keywords: | Edulcorants sintètics Càncer Nonnutritive sweetener Cancer |
Issue Date: | 16-Jun-2023 |
Publisher: | Wiley |
Abstract: | Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (<greater than or equal to> third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR=1.58, 95% CI 1.05-2.41, P trend=.03) and stomach cancer (OR=2.27 [0.99-5.44], P trend=.06). High consumption of aspartame, was associated with stomach cancer (OR=2.04 [0.7-5.4], P trend=.05), while a lower risk was observed for breast cancer (OR=0.28 [0.08-0.83], P trend=.03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/ijc.34577 |
It is part of: | International Journal of Cancer, 2023, vol. 153, num. 5, p. 979-993 |
URI: | http://hdl.handle.net/2445/202622 |
Related resource: | https://doi.org/10.1002/ijc.34577 |
ISSN: | 1097-0215 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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Intl Journal of Cancer - 2023 - Palomar‐Cros.pdf | 2.15 MB | Adobe PDF | View/Open |
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