Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/202708
Title: Differential Immune Response to Bioprosthetic Heart Valve Tissues in the α1,3Galactosyltransferase-Knockout Mouse Model
Author: Casós, Kelly
Llatjós, Roger
Blasco Lucas, Arnau
Kuguel, Sebastián G.
Sbraga, Fabrizio
Galli, Cesare
Padler-Karavani, Vered
Tourneau, Thierry Le
Vadori, Marta
Perota, Andrea
Roussel, Jean Christian
Bottio, Tomaso
Cozzi, Emanuele
Soulillou, Jean Paul
Galiñanes, Manuel
Máñez, Rafael
Costa, Cristina
Keywords: Pròtesis valvulars cardíaques
Resposta immunitària
Heart valve prosthesis
Immune response
Issue Date: 13-Jul-2023
Publisher: MDPI AG
Abstract: Structural valve deterioration (SVD) of bioprosthetic heart valves (BHVs) has great clinical and economic consequences. Notably, immunity against BHVs plays a major role in SVD, especially when implanted in young and middle-aged patients. However, the complex pathogenesis of SVD remains to be fully characterized, and analyses of commercial BHVs in standardized-preclinical settings are needed for further advancement. Here, we studied the immune response to commercial BHV tissue of bovine, porcine, and equine origin after subcutaneous implantation into adult a1,3-galactosyltransferase-knockout (Gal KO) mice. The levels of serum anti-galactose a1,3-galactose (Gal) and -non-Gal IgM and IgG antibodies were determined up to 2 months post-implantation. Based on histological analyses, all BHV tissues studied triggered distinct infiltrating cellular immune responses that related to tissue degeneration. Increased anti-Gal antibody levels were found in serum after ATS 3f and Freedom/Solo implantation but not for Crown or Hancock II grafts. Overall, there were no correlations between cellular-immunity scores and post-implantation antibodies, suggesting these are independent factors differentially affecting the outcome of distinct commercial BHVs. These findings provide further insights into the understanding of SVD immunopathogenesis and highlight the need to evaluate immune responses as a confounding factor.
Note: Reproducció del document publicat a: https://doi.org/10.3390/bioengineering10070833
It is part of: Bioengineering, 2023, vol. 10, num. 7
URI: http://hdl.handle.net/2445/202708
Related resource: https://doi.org/10.3390/bioengineering10070833
ISSN: 2306-5354
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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