Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/202708
Title: | Differential Immune Response to Bioprosthetic Heart Valve Tissues in the α1,3Galactosyltransferase-Knockout Mouse Model |
Author: | Casós, Kelly Llatjós, Roger Blasco Lucas, Arnau Kuguel, Sebastián G. Sbraga, Fabrizio Galli, Cesare Padler-Karavani, Vered Tourneau, Thierry Le Vadori, Marta Perota, Andrea Roussel, Jean Christian Bottio, Tomaso Cozzi, Emanuele Soulillou, Jean Paul Galiñanes, Manuel Máñez, Rafael Costa, Cristina |
Keywords: | Pròtesis valvulars cardíaques Resposta immunitària Heart valve prosthesis Immune response |
Issue Date: | 13-Jul-2023 |
Publisher: | MDPI AG |
Abstract: | Structural valve deterioration (SVD) of bioprosthetic heart valves (BHVs) has great clinical and economic consequences. Notably, immunity against BHVs plays a major role in SVD, especially when implanted in young and middle-aged patients. However, the complex pathogenesis of SVD remains to be fully characterized, and analyses of commercial BHVs in standardized-preclinical settings are needed for further advancement. Here, we studied the immune response to commercial BHV tissue of bovine, porcine, and equine origin after subcutaneous implantation into adult a1,3-galactosyltransferase-knockout (Gal KO) mice. The levels of serum anti-galactose a1,3-galactose (Gal) and -non-Gal IgM and IgG antibodies were determined up to 2 months post-implantation. Based on histological analyses, all BHV tissues studied triggered distinct infiltrating cellular immune responses that related to tissue degeneration. Increased anti-Gal antibody levels were found in serum after ATS 3f and Freedom/Solo implantation but not for Crown or Hancock II grafts. Overall, there were no correlations between cellular-immunity scores and post-implantation antibodies, suggesting these are independent factors differentially affecting the outcome of distinct commercial BHVs. These findings provide further insights into the understanding of SVD immunopathogenesis and highlight the need to evaluate immune responses as a confounding factor. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/bioengineering10070833 |
It is part of: | Bioengineering, 2023, vol. 10, num. 7 |
URI: | http://hdl.handle.net/2445/202708 |
Related resource: | https://doi.org/10.3390/bioengineering10070833 |
ISSN: | 2306-5354 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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bioengineering-10-00833.pdf | 4.9 MB | Adobe PDF | View/Open |
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