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http://hdl.handle.net/2445/202881
Title: | C-Reactive Protein, a Promising Approach for Acetaminophen Hepatotoxicity |
Author: | García Ruiz, Carmen Fernández Checa Torres, José Carlos |
Issue Date: | 31-Oct-2021 |
Publisher: | Elsevier BV |
Abstract: | Drug-induced liver injury is a major cause of acute liver failure (ALF) and one of the most challenging liver disorders with respect to its prediction, diagnosis, and management. Acetaminophen (APAP) is one of the most widely used pain relievers worldwide. Although relatively safe, APAP is a dose-dependent hepatotoxin and APAP overdose is a major cause of ALF, far exceeding other causes of ALF in industrialized countries. APAP hepatotoxicity in humans can be modelled in rodents after administration of an acute or cumulative overdose. However, despite intensive efforts, the mechanisms involved in APAP hepatotoxicity are not fully understood, which has hampered the availability of effective therapy for APAP hepatotoxicity.1,2 N-acetylcysteine (NAC) is the standard treatment for APAP hepatotoxicity and other causes of ALF.3 However, the effectiveness of NAC in APAP hepatotoxicity is limited to early administration, indicating the need to identify new strategies for adequate management of ALF caused by APAP hepatotoxicity. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.jcmgh.2021.10.004 |
It is part of: | Cellular and Molecular Gastroenterology and Hepatology, 2022, vol. 13, num. 1, p. 341-342 |
URI: | http://hdl.handle.net/2445/202881 |
Related resource: | https://doi.org/10.1016/j.jcmgh.2021.10.004 |
ISSN: | 2352-345X |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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C-Reactive Protein, a Promising Approach for Acetaminophen_CellularAndMolecularGastro.pdf | 203.46 kB | Adobe PDF | View/Open |
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