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http://hdl.handle.net/2445/203046
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DC Field | Value | Language |
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dc.contributor.author | Kulis, Marta | - |
dc.contributor.author | Martín Subero, José Ignacio | - |
dc.date.accessioned | 2023-10-23T13:05:56Z | - |
dc.date.available | 2023-10-23T13:05:56Z | - |
dc.date.issued | 2023-02-01 | - |
dc.identifier.issn | 1365-2141 | - |
dc.identifier.uri | http://hdl.handle.net/2445/203046 | - |
dc.description.abstract | Chronic lymphocytic leukaemia (CLL) is not only characterised by driver genetic alterations but by extensive epigenetic changes. Over the last decade, epigenomic studies have described the DNA methylome, chromatin accessibility, histone modifications and the three-dimensional (3D) genome architecture of CLL. Beyond its regulatory role, the DNA methylome contains imprints of the cellular origin and proliferative history of CLL cells. These two aspects are strong independent prognostic factors. Integrative analyses of chromatin marks have uncovered novel regulatory elements and altered transcription factor networks as non-genetic means mediating gene deregulation in CLL. Additionally, CLL cells display a disease-specific pattern of 3D genome interactions. From the technological perspective, we are currently witnessing a transition from bulk omics to single-cell analyses. This review aims at summarising the major findings from the epigenomics field as well as providing a prospect of the present and future of single-cell analyses in CLL.© 2022 British Society for Haematology and John Wiley & Sons Ltd. | - |
dc.format.extent | 29 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | John Wiley and Sons | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1111/bjh.18465 | - |
dc.relation.ispartof | British Journal Of Haematology, 2023, vol. 200, num. 3, p. 280-290 | - |
dc.relation.uri | https://doi.org/10.1111/bjh.18465 | - |
dc.rights | (c) British Society for Haematology and John Wiley & Sons, 2022 | - |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Leucèmia limfocítica crònica | - |
dc.subject.classification | Epigenètica | - |
dc.subject.other | Chronic lymphocytic leukemia | - |
dc.subject.other | Epigenetics | - |
dc.title | Integrative epigenomics in chronic lymphocytic leukaemia: Biological insights and clinical applications | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2023-10-16T08:28:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9329892 | - |
dc.identifier.pmid | 36121003 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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Kulis_Martin-Subero_BJH 2023_version aceptada.pdf | 1.18 MB | Adobe PDF | View/Open |
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