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http://hdl.handle.net/2445/203359
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DC Field | Value | Language |
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dc.contributor.author | Barrio, Lara | - |
dc.contributor.author | Gaspar, Ana Elena | - |
dc.contributor.author | Muzzopappa, Mariana | - |
dc.contributor.author | Ghosh, Kaustuv | - |
dc.contributor.author | Romão, Daniela | - |
dc.contributor.author | Clemente Ruiz, Marta | - |
dc.contributor.author | Milán, Marco | - |
dc.date.accessioned | 2023-11-03T10:10:30Z | - |
dc.date.issued | 2023-09-25 | - |
dc.identifier.issn | 1879-0445 | - |
dc.identifier.uri | http://hdl.handle.net/2445/203359 | - |
dc.description.abstract | Chromosomal instability (CIN), an increased rate of changes in chromosome structure and number, is observed in most sporadic human carcinomas with high metastatic activity. Here, we use a Drosophila epithelial model to show that DNA damage, as a result of the production of lagging chromosomes during mitosis and aneuploidy-induced replicative stress, contributes to CIN-induced invasiveness. We unravel a sub-lethal role of effector caspases in invasiveness by enhancing CIN-induced DNA damage and identify the JAK/STAT signaling pathway as an activator of apoptotic caspases through transcriptional induction of pro-apoptotic genes. We provide evidence that an autocrine feedforward amplification loop mediated by Upd3-a cytokine with homology to interleukin-6 and a ligand of the JAK/STAT signaling pathway-contributes to amplifying the activation levels of the apoptotic pathway in migrating cells, thus promoting CIN-induced invasiveness. This work sheds new light on the chromosome-signature-independent effects of CIN in metastasis.Copyright © 2023 Elsevier Inc. All rights reserved. | ca |
dc.format.extent | 40 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | Elsevier | ca |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.cub.2023.09.004 | - |
dc.relation.ispartof | Current Biology, 2023, vol. 33, num. 20, p. 4446-4457 | - |
dc.relation.uri | https://doi.org/10.1016/j.cub.2023.09.004 | - |
dc.rights | cc-by-nc-nd (c) Elsevier, 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) | - |
dc.subject.classification | Mitosi | - |
dc.subject.classification | Anomalies cromosòmiques | - |
dc.subject.other | Mitosis | - |
dc.subject.other | Chromosome abnormalities | - |
dc.title | Chromosomal instability-induced cell invasion through caspase-driven DNA damage | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-11-03T09:44:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | ca |
dc.embargo.lift | 2024-09-25 | - |
dc.date.embargoEndDate | info:eu-repo/date/embargoEnd/2024-09-25 | ca |
dc.identifier.idimarina | 6603070 | - |
dc.identifier.pmid | 37751744 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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File | Description | Size | Format | |
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Curr Biol_Barrio et al_2023.pdf | 4.7 MB | Adobe PDF | View/Open Request a copy |
Document embargat fins el
25-9-2024
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