Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/203656
Title: | Maternal obesity damages the median eminence blood-brain barrier structure and function in the progeny: the beneficial impact of cross-fostering by lean mothers |
Author: | Haddad Tovolli, Roberta Morari, Joseane Barbizan, Roberta Bóbbo, Vanessa Carraro, Rodrigo Solon, Carina Dragano, Nathalia Torsoni, Márcio Araujo, Eliana Velloso, Licio |
Keywords: | Obesitat Maternitat Obesity Motherhood |
Issue Date: | 2-Feb-2023 |
Publisher: | The American Physiological Society |
Abstract: | Maternal dietary habits directly influence offspring health. In this study, we aimed at determining the impact of maternal obesity on BBB integrity. We show that DIO offspring presented a leakier ME–BBB, accompanied by changes in the expression of transcripts encoding for endothelial and tanycytic proteins, as well as of hypothalamic neuropeptides. Breastfeeding in lean dams was sufficient to protect the offspring from ME–BBB disruption, providing a preventive strategy of nutritional intervention during early life. |
URI: | http://hdl.handle.net/2445/203656 |
Related resource: | https://doi.org/10.1152/ajpendo.00268.2022 |
ISSN: | 1522-1555 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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Haddad-Tovolli_2023._Maternal.pdf | 10.36 MB | Adobe PDF | View/Open |
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