Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/203763
Title: | Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis |
Author: | Domingo Muelas, Ana Duart Abadia, Pere Morante Redolat, José Manuel Jordán Pla, Antonio Belenguer, Germán Fabra Beser, Jaime Paniagua Herranz, Lucía Pérez Villalba, Ana Álvarez Varela, Adrián Barriga, Francisco M. Gil Sanz, Cristina Ortega, Felipe Batlle, Eduard Fariñas, Isabel |
Keywords: | Neurogenètica RNA Neurogenetics RNA |
Issue Date: | 23-Jan-2023 |
Publisher: | Springer Nature |
Abstract: | Neural stem cells (NSCs) in the adult murine subependymal zone balance their self-renewal capacity and glial identity with the potential to generate neurons during the lifetime. Adult NSCs exhibit lineage priming via pro-neurogenic fate determinants. However, the protein levels of the neural fate determinants are not sufficient to drive direct differentiation of adult NSCs, which raises the question of how cells along the neurogenic lineage avoid different conflicting fate choices, such as self-renewal and differentiation. Here, we identify RNA-binding protein MEX3A as a post-transcriptional regulator of a set of stemness associated transcripts at critical transitions in the subependymal neurogenic lineage. MEX3A regulates a quiescence-related RNA signature in activated NSCs that is needed for their return to quiescence, playing a role in the long-term maintenance of the NSC pool. Furthermore, it is required for the repression of the same program at the onset of neuronal differentiation. Our data indicate that MEX3A is a pivotal regulator of adult murine neurogenesis acting as a translational remodeller.© 2023. The Author(s). |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-023-36054-6 |
It is part of: | Nature Communications, 2023, vol. 14, num. 1 |
URI: | http://hdl.handle.net/2445/203763 |
Related resource: | https://doi.org/10.1038/s41467-023-36054-6 |
ISSN: | 2041-1723 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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NatCommun_Domingo-Muelas et al_2023.pdf | 3.92 MB | Adobe PDF | View/Open |
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