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http://hdl.handle.net/2445/204083
Title: | Infectiousness of patients with smear-negative pulmonary tuberculosis, assessed by Real-time Polymerase Chain Reaction, Xpert®MTB/RIF |
Author: | Camprubí, Daniel Gomila Grange, Aina Grijota Camino, Maria D. Soldevila, Laura Luque, Maria J. Alcaide Fernández de Vega, Fernando Dorca i Sargatal, Jordi Santín Cerezales, Miguel |
Keywords: | Tuberculosi Reacció en cadena de la polimerasa Tuberculosis Polymerase chain reaction |
Issue Date: | Mar-2020 |
Publisher: | Elsevier |
Abstract: | Currently, pulmonary tuberculosis (TB) isolation recommendations are based on serial sputum smear microscopy. To assess infectiousness of smear-negative/GeneXpert-positive (Sm-/GXpert+) pulmonary TB, we evaluated 511 contacts of pulmonary TB patients attended at a teaching hospital in Spain (2010-2018). There were no statistically significant differences in rates of Mycobacterium tuberculosis infection (46.2% contacts of smear-positive and 34.6% contacts of Sm-/GXpert+ pulmonary TB patients, p=0.112). Sm-/GXpert+ pulmonary TB poses a substantial risk of transmission of M. tuberculosis infection. Our results add evidence to support including Real-time Polymerase Chain Reaction (Xpert®MTB/RIF) in the work-up diagnosis of suspected pulmonary TB cases to make decisions on air-borne isolation. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.jinf.2019.12.023 |
It is part of: | Journal of Infection, 2020, vol. 80, num.3, p. 298-300 |
URI: | http://hdl.handle.net/2445/204083 |
Related resource: | https://doi.org/10.1016/j.jinf.2019.12.023 |
ISSN: | 0163-4453 |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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