Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/204382
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Marques da Costa, Maria Eugénia | - |
dc.contributor.author | Zaidi, Sakina | - |
dc.contributor.author | Scoazec, Jean Yves | - |
dc.contributor.author | Droit, Robin | - |
dc.contributor.author | Lim, Wan Ching | - |
dc.contributor.author | Marchais, Antonin | - |
dc.contributor.author | Salmon, Jerome | - |
dc.contributor.author | Cherkaoui, Sarah | - |
dc.contributor.author | Morscher, Raphael J. | - |
dc.contributor.author | Laurent, Anouchka | - |
dc.contributor.author | Malinge, Sébastien | - |
dc.contributor.author | Mercher, Thomas | - |
dc.contributor.author | Tabone Eglinger, Séverine | - |
dc.contributor.author | Goddard, Isabelle | - |
dc.contributor.author | Pflumio, Francoise | - |
dc.contributor.author | Calvo, Julien | - |
dc.contributor.author | Redini, Francoise | - |
dc.contributor.author | Entz-Werlé, Natacha | - |
dc.contributor.author | Soriano, Aroa | - |
dc.contributor.author | Villanueva, Alberto | - |
dc.contributor.author | Cairo, Stefano | - |
dc.contributor.author | Chastagner, Pascal | - |
dc.contributor.author | Moro, Massimo | - |
dc.contributor.author | Owens, Cormac | - |
dc.contributor.author | Casanova, Michela | - |
dc.contributor.author | Hladun Alvaro, Raquel | - |
dc.contributor.author | Berlanga, Pablo | - |
dc.contributor.author | Daudigeos Dubus, Estelle | - |
dc.contributor.author | Dessen, Philippe | - |
dc.contributor.author | Zitvogel, Laurence | - |
dc.contributor.author | Lacroix, Ludovic | - |
dc.contributor.author | Pierron, Gaelle | - |
dc.contributor.author | Delattre, Olivier | - |
dc.contributor.author | Schleiermacher, Gudrun | - |
dc.contributor.author | Surdez, Didier | - |
dc.contributor.author | Geoerger, Birgit | - |
dc.date.accessioned | 2023-12-11T09:58:15Z | - |
dc.date.available | 2023-12-11T09:58:15Z | - |
dc.date.issued | 2023-09-18 | - |
dc.identifier.issn | 2399-3642 | - |
dc.identifier.uri | http://hdl.handle.net/2445/204382 | - |
dc.description.abstract | Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial (NCT02613962). To date, 131 PDX models were established following heterotopical and/or orthotopical implantation in immunocompromised mice: 76 sarcomas, 25 other solid tumors, 12 central nervous system tumors, 15 acute leukemias, and 3 lymphomas. PDX establishment rate was 43%. Histology, whole exome and RNA sequencing revealed a high concordance with the primary patient's tumor profile, human leukocyte-antigen characteristics and specific metabolic pathway signatures. A detailed patient molecular characterization, including specific mutations prioritized in the clinical molecular tumor boards are provided. Ninety models were shared with the IMI2 ITCC Pediatric Preclinical Proof-of-concept Platform (IMI2 ITCC-P4) for further exploitation. This PDX biobank of unique recurrent childhood cancers provides an essential support for basic and translational research and treatments development in advanced pediatric malignancies. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science and Business Media LLC | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s42003-023-05320-0 | - |
dc.relation.ispartof | Communications Biology, 2023, vol. 6, num. 1 | - |
dc.relation.uri | https://doi.org/10.1038/s42003-023-05320-0 | - |
dc.rights | cc by (c) Marques da Costa, Maria Eugénia et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Pediatria | - |
dc.subject.other | Cancer | - |
dc.subject.other | Pediatrics | - |
dc.title | A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-10-25T10:43:20Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 37723198 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
s42003-023-05320-0.pdf | 2.85 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License