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http://hdl.handle.net/2445/204390
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DC Field | Value | Language |
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dc.contributor.author | Tsagiopoulou, Maria | - |
dc.contributor.author | Chapaprieta, Vicente | - |
dc.contributor.author | Russiñol, Nuria | - |
dc.contributor.author | García Torre, Beatriz | - |
dc.contributor.author | Pechlivanis, Nikolaos | - |
dc.contributor.author | Nadeu, Ferran | - |
dc.contributor.author | Papakonstantinou, Nikos | - |
dc.contributor.author | Stavroyianni, Niki | - |
dc.contributor.author | Chatzidimitriou, Anastasia | - |
dc.contributor.author | Psomopoulos, Fotis | - |
dc.contributor.author | Campo Güerri, Elias | - |
dc.contributor.author | Stamatopoulos, Kostas | - |
dc.contributor.author | Martín Subero, José Ignacio | - |
dc.date.accessioned | 2023-12-11T11:32:15Z | - |
dc.date.available | 2024-06-15T05:10:14Z | - |
dc.date.issued | 2023-06-15 | - |
dc.identifier.issn | 1528-0020 | - |
dc.identifier.uri | http://hdl.handle.net/2445/204390 | - |
dc.description.abstract | The chromatin activation landscape of chronic lymphocytic leukemia (CLL) with stereo-typed B-cell receptor immunoglobulin is currently unknown. In this study, we report the results of a whole-genome chromatin profiling of histone 3 lysine 27 acetylation of 22 CLLs from major subsets, which were compared against nonstereotyped CLLs and normal B-cell subpopulations. Although subsets 1, 2, and 4 did not differ much from their non-stereotyped CLL counterparts, subset 8 displayed a remarkably distinct chromatin acti-vation profile. In particular, we identified 209 de novo active regulatory elements in this subset, which showed similar patterns with U-CLLs undergoing Richter transformation. These regions were enriched for binding sites of 9 overexpressed transcription factors. In 78 of 209 regions, we identified 113 candidate overexpressed target genes, 11 regions being associated with more than 2 adjacent genes. These included blocks of up to 7 genes, suggesting local coupregulation within the same genome compartment. Our findings further underscore the uniqueness of subset 8 CLL, notable for the highest risk of Richter's transformation among all CLLs and provide additional clues to decipher the molecular basis of its clinical behavior. | ca |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1182/blood.2022016587 | - |
dc.relation.ispartof | Blood, 2023, vol. 141, num. 24, p. 2955-2960 | - |
dc.relation.uri | https://doi.org/10.1182/blood.2022016587 | - |
dc.rights | (c) American Society of Hematology, 2023 | - |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Leucèmia limfocítica crònica | - |
dc.subject.classification | Cromatina | - |
dc.subject.other | Chronic lymphocytic leukemia | - |
dc.subject.other | Chromatin | - |
dc.title | Chromatin activation profiling of stereotyped chronic lymphocytic leukemias reveals a subset 8-specific signature | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-11-30T11:00:16Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9349572 | - |
dc.identifier.pmid | 36989492 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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Tsagiopoulou et al_accepted version 2023.pdf | 1.83 MB | Adobe PDF | View/Open |
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