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http://hdl.handle.net/2445/204400
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DC Field | Value | Language |
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dc.contributor.author | Ruiz Cáceres, Inmaculada | - |
dc.contributor.author | Hermida Romero, Teresa | - |
dc.contributor.author | Guerra Merino, Isabel | - |
dc.contributor.author | Portu Zapirain, Joseba | - |
dc.contributor.author | Pérez Mies, Belén | - |
dc.contributor.author | Sánchez Conde, Matilde | - |
dc.contributor.author | Alonso Riaño, Marina | - |
dc.contributor.author | Rubio Campillo, Rafael | - |
dc.contributor.author | Fortés Alen, Jose | - |
dc.contributor.author | Vidal González, Ánxela | - |
dc.contributor.author | Salas Antón, Clara | - |
dc.contributor.author | Múñez, Elena | - |
dc.contributor.author | Sánchez Sánchez, Rafael | - |
dc.contributor.author | Corona Mata, Diana | - |
dc.contributor.author | Aldecoa Ansorregui, Iban | - |
dc.contributor.author | Miró, José M. | - |
dc.contributor.author | Beloqui Pérez de Obanos, Raquel | - |
dc.contributor.author | Ibero, Carlos | - |
dc.contributor.author | Gómez Román, Javier | - |
dc.contributor.author | Fariñas, María Carmen | - |
dc.contributor.author | Tabuyo Bello, Teresa | - |
dc.contributor.author | Alava, Enrique de | - |
dc.contributor.author | Cisneros, José Miguel | - |
dc.contributor.author | Matias-Guiu, Xavier | - |
dc.contributor.author | Rivero, Antonio | - |
dc.contributor.author | NecroCOVID Study Group | - |
dc.date.accessioned | 2023-12-11T09:53:16Z | - |
dc.date.available | 2023-12-11T09:53:16Z | - |
dc.date.issued | 2023-07-04 | - |
dc.identifier.issn | 2296-858X | - |
dc.identifier.uri | http://hdl.handle.net/2445/204400 | - |
dc.description.abstract | IntroductionWhole-body autopsies may be crucial to understand coronavirus disease 2019 (COVID-19) pathophysiology. We aimed to analyze pathological findings in a large series of full-body autopsies, with a special focus on superinfections. MethodsThis was a prospective multicenter study that included 70 COVID-19 autopsies performed between April 2020 and February 2021. Epidemiological, clinical and pathological information was collected using a standardized case report form. ResultsMedian (IQR) age was 70 (range 63.75-74.25) years and 76% of cases were males. Most patients (90%,) had at least one comorbidity prior to COVID-19 diagnosis, with vascular risk factors being the most frequent. Infectious complications were developed by 65.71% of the patients during their follow-up. Mechanical ventilation was required in most patients (75.71%) and was mainly invasive. In multivariate analyses, length of hospital stay and invasive mechanical ventilation were significantly associated with infections (p = 0.036 and p = 0.013, respectively). Necropsy findings revealed diffuse alveolar damage in the lungs, left ventricular hypertrophy in the heart, liver steatosis and pre-infection arteriosclerosis in the heart and kidneys. ConclusionOur study confirms the main necropsy histopathological findings attributed to COVID-19 in a large patient series, while underlining the importance of both comorbid conditions and superinfections in the pathology. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media SA | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fmed.2023.1151843 | - |
dc.relation.ispartof | Frontiers in Medicine, 2023, vol. 10 | - |
dc.relation.uri | https://doi.org/10.3389/fmed.2023.1151843 | - |
dc.rights | cc by (c) Ruiz Cáceres, Inmaculada et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Fisiologia patològica | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Pathological physiology | - |
dc.title | Post-mortem findings in Spanish patients with COVID-19; a special focus on superinfections | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-08-17T13:02:29Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 37484846 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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fmed-10-1151843.pdf | 523.83 kB | Adobe PDF | View/Open |
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