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http://hdl.handle.net/2445/204481
Title: | Loss of Visceral Fat is Associated with a Reduction in Inflammatory Status in Patients with Metabolic Syndrome |
Author: | Castro-Barquero, S Casas, R Rimm, Eric B. Tresserra i Rimbau, Anna Romaguera, Dora Martínez Hernández, José Alfredo Salas Salvadó, Jordi Martínez-González, Miguel Ángel, 1957- Vidal Cortada, Josep Ruiz Canela, Miguel Konieczna, Jadwiga Sacanella, Emilio García Gavilán, Jesús Fitó Colomer, Montserrat García Arellano, Ana Estruch Riba, Ramon |
Keywords: | Teixit adipós Malalties inflamatòries intestinals Adipose tissues Inflammatory bowel diseases |
Issue Date: | Feb-2023 |
Publisher: | Wiley-VCH |
Abstract: | Scope: Excessive visceral adipose tissue (VAT) is associated with higher secretion of pro-inflammatory molecules, contributing to systemic inflammation and obesity-related metabolic disturbances. Methods & results: This prospective analysis includes 117 overweight/obese adults (55-75 years) from the PREDIMED-Plus study. Fourteen inflammatory markers and adipokines were measured using a Bio-Plex assay with multiplex technology: insulin, glucagon, IL-6, visfatin, ghrelin, GLP-1, TNF-α, MCP-1, PAI-1, resistin, C-peptide, leptin, adipsin and adiponectin. Participants were categorized into tertiles according to changes in VAT after 1-year of follow-up, determined by dual-energy X-Ray absorptiometry. Participants allocated in tertile 3, which represent an increase of VAT content after 1-year of follow-up compared to tertile 1, showed significant differences in insulin (T3 versus T1, fully adjusted model: p = 0.037, p for trend 0.042), PAI-1 (fully adjusted model: p = 0.05, p for trend 0.06), c-peptide (fully adjusted model: p = 0.037, p for trend 0.042), and TNF-α (fully adjusted model p = 0.037, p for trend 0.042). Conclusion: Our results evidenced that a reduction in VAT was associated with clinical improvements in several inflammatory and adiposity markers, mainly in insulin, c-peptide, and PAI-1 levels, and these improvements may contribute to a reduction in cardiometabolic disturbances observed in obesity. This article is protected by copyright. All rights reserved. Keywords: Adipokines; Inflammation; Lifestyle; Mediterranean diet; Visceral adipose tissue. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/mnfr.202200264 |
It is part of: | Molecular Nutrition & Food Research, 2023, vol. 67 |
URI: | http://hdl.handle.net/2445/204481 |
Related resource: | https://doi.org/10.1002/mnfr.202200264 |
ISSN: | 1613-4125 |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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