Please use this identifier to cite or link to this item:
Title: Therapeutic applications of essential oils from native and cultivated ecuadorian plants: Cutaneous candidiasis and dermal anti-inflammatory activity
Author: Sosa Díaz, Lilian Elisa
Espinoza, Lupe Carolina
Valarezo, Eduardo
Bozal de Febrer, Núria
Calpena Campmany, Ana Cristina
Fábrega Fernández, María José
Baldomà Llavinés, Laura
Rincón, María
Mallandrich Miret, Mireia
Keywords: Olis essencials
Essences and essential oils
Issue Date: 5-Aug-2023
Publisher: MDPI
Abstract: Abstract: Essential oils are a complex mixture of aromatic substances whose pharmacological actions, including antimicrobial, antioxidant, anticancer, and anti-inflammatory activities, have been widely reported. This study aimed to evaluate the anti-Candida and dermal anti-inflammatory activity of essential oils from native and cultivated Ecuadorian plants. Essential oils from Bursera graveolens, Dacryodes peruviana, Mespilodaphne quixos, and Melaleuca armillaris were isolated by hydrodistillation and were characterized physically and chemically. Its tolerance was analyzed by in vitro and in vivo studies. The antifungal activity was studied against Candida albicans, Candida glabrata, and Candida parapsilosis, whereas the anti-inflammatory effect was evaluated by a mouse ear edema model. The main compounds were limonene, -phellandrene, (E)-methyl cinnamate, and 1,8-cineole, respectively. All essential oils showed high tolerability for skin application, antifungal activity against the three Candida strains, and anti-inflammatory efficacy by decreasing edema and overexpression of pro-inflammatory cytokines. Dacryodes peruviana essential oil showed the highest antifungal activity. On the other hand, Dacryodes peruviana and Melaleuca armillaris showed the greatest anti-inflammatory potential, decreasing edema by 53.3% and 65.25%, respectively, and inhibiting the overexpression of TNF- , IL-8, IL-17A, and IL-23. The results suggest that these essential oils could be used as alternative therapies in the treatment of both cutaneous candidiasis and dermal inflammation.
Note: Reproducció del document publicat a:
It is part of: Molecules, 2023, vol. 28, num.15, p. 1-18
Related resource:
ISSN: 1420-3049
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

Files in This Item:
File Description SizeFormat 
827607.pdf3.19 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons