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Title: | Age at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women |
Author: | Tschiderer, Lena Peters, Sanne A. E. Schouw, Yvonne T. van der Westing, Anniek C. van Tong, Tammy Y. N. Willeit, Peter Seekircher, Lisa Moreno Iribas, Conchi Huerta, José María Crous Bou, Marta Söderholm, Martin Schulze, Matthias B. Johansson, Cecilia Själander, Sara Heath, Alicia K. Macciotta, Alessandra Dahm, Christina C. Ibsen, Daniel B. Pala, Valeria Mellemkjær, Lene Burgess, Stephen Wood, Angela Kaaks, Rudolf Katzke, Verena Amiano, Pilar Rodriguez Barranco, Miguel Engström, Gunnar Weiderpass, Elisabete Tjønneland, Anne Halkjær, Jytte Panico, Salvatore Danesh, John Butterworth, Adam Onland Moret, N. Charlotte |
Keywords: | Menopausa Malalties del cor Menopause Heart diseases |
Issue Date: | 8-Sep-2023 |
Publisher: | Ovid Technologies (Wolters Kluwer Health) |
Abstract: | Background: Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear. Methods and Results: We analyzed data of the UK Biobank and EPIC-CVD (European Prospective Investigation Into Cancer and Nutrition-Cardiovascular Diseases) study. A total of 204244 postmenopausal women without a history of stroke at baseline were included (7883 from EPIC-CVD [5292 from the subcohort], 196361 from the UK Biobank). Pooled mean baseline age was 58.9years (SD, 5.8), and pooled mean age at menopause was 47.8years (SD, 6.2). Over a median follow-up of 12.6years (interquartile range, 11.8-13.3), 6770 women experienced a stroke (5155 ischemic strokes, 1615 hemorrhagic strokes, 976 intracerebral hemorrhages, and 639 subarachnoid hemorrhages). In multivariable adjusted observational Cox regression analyses, the pooled hazard ratios per 5years younger age at menopause were 1.09 (95% CI, 1.07-1.12) for stroke, 1.09 (95% CI, 1.06-1.13) for ischemic stroke, 1.10 (95% CI, 1.04-1.16) for hemorrhagic stroke, 1.14 (95% CI, 1.08-1.20) for intracerebral hemorrhage, and 1.00 (95% CI, 0.84-1.20) for subarachnoid hemorrhage. When using 2-sample Mendelian randomization analysis, we found no statistically significant association between genetically proxied age at menopause and risk of any type of stroke. Conclusions: In our study, earlier age at menopause was related to a higher risk of stroke. We found no statistically significant association between genetically proxied age at menopause and risk of stroke, suggesting no causal relationship. |
Note: | Reproducció del document publicat a: https://doi.org/10.1161/JAHA.123.030280 |
It is part of: | Journal of the American Heart Association, 2023, vol. 12, num. 18 |
URI: | http://hdl.handle.net/2445/205332 |
Related resource: | https://doi.org/10.1161/JAHA.123.030280 |
ISSN: | 2047-9980 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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