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Title: Neuregulins mediate calcium-induced glucose transport during muscle contraction
Author: Cantó, Carles
Chibalin, Alexander V.
Barnes, Brian R.
Glund, Stephan
Suárez, Elisabet
Ryder, Jeffrey W.
Palacín Prieto, Manuel
Zierath, Juleen R.
Zorzano Olarte, Antonio
Gumà i Garcia, Anna Maria
Keywords: Factors de creixement
Contracció muscular
Growth factors
Muscle contraction
Issue Date: 4-Aug-2006
Publisher: American Society for Biochemistry and Molecular Biology
Abstract: Neuregulin, a growth factor involved in myogenesis, has rapid effects on muscle metabolism. In a manner analogous to insulin and exercise, neuregulins stimulate glucose transport through recruitment of glucose transporters to surface membranes in skeletal muscle. Like muscle contraction, neuregulins have additive effects with insulin on glucose uptake. Therefore, we examined whether neuregulins are involved in the mechanism by which muscle contraction regulates glucose transport. We show that caffeine-induced increases in cytosolic Ca2+ mediate a metalloproteinase-dependent release of neuregulins, which stimulates tyrosine phosphorylation of ErbB4 receptors. Activation of ErbB4 is necessary for Ca2+-derived effects on glucose transport. Furthermore, blockage of ErbB4 abruptly impairs contraction-induced glucose uptake in slow twitch muscle fibers, and to a lesser extent, in fast twitch muscle fibers. In conclusion, we provide evidence that contraction-induced activation of neuregulin receptors is necessary for the stimulation of glucose transport and a key element of energetic metabolism during muscle contraction.
Note: Reproducció del document publicat a:
It is part of: Journal of Biological Chemistry, 2006, vol. 281, num.31, p. 21690-21697
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ISSN: 0021-9258
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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