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http://hdl.handle.net/2445/206164
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DC Field | Value | Language |
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dc.contributor.author | Gomez, Miquel | - |
dc.contributor.author | Arias Guillén, Marta | - |
dc.contributor.author | Maduell Canals, Francesc | - |
dc.date.accessioned | 2024-01-23T12:59:14Z | - |
dc.date.available | 2024-01-23T12:59:14Z | - |
dc.date.issued | 2023-03-18 | - |
dc.identifier.issn | 1724-6040 | - |
dc.identifier.uri | http://hdl.handle.net/2445/206164 | - |
dc.description.abstract | The hemoconcentration effect for middle weight solutes in hemodialysis is corrected by oversimplified methods based on hematocrit changes or distribution volume variations. Here we implemented a variable volume dual pool kinetic model targeted at obtaining a precise correction factor equation for extracellularly distributed solutes based on relevant kinetic parameters such as the ultrafiltration to dry weight ratio UF/DW, the dialyzer clearance, Kd, the intercompartment mass-transfer coefficient, Kc, and the central compartment to extracellular volume ratio, α. More than 300,000 solutions of the model were computed, performing a sweep among physiological values of the proposed kinetic parameters, resulting in a linear regression denoted by the expression fcorr = 1.0707 - 5.2246 (UF/DW) - 0.0005 Kd - 0.0004 Kc - 0.0007 α, with an excellent coefficient of determination R2 = 0.983. The presented fcorr provides a substantial extension of the currently implemented methods to estimate the hemoconcentration factor for middle and high molecular weight extracellular distributed solutes in hemodialysis. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1177/03913988231160803 | - |
dc.relation.ispartof | International Journal Of Artificial Organs, 2023, vol. 46, num. 5, p. 314-317 | - |
dc.relation.uri | https://doi.org/10.1177/03913988231160803 | - |
dc.rights | (c) The International Journal of Artificial Organs, 2023 | - |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Hemodiàlisi | - |
dc.subject.classification | Cinética química | - |
dc.subject.other | Hemodialysis | - |
dc.subject.other | Chemical kinetics | - |
dc.title | An extended kinetic model-based correction factor equation to account hemodialysis post-treatment hemoconcentration | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2024-01-23T12:00:03Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9348113 | - |
dc.identifier.pmid | 36932951 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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JAO-22-0159.R1_Proof_hi.pdf | 503.36 kB | Adobe PDF | View/Open |
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