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DC Field | Value | Language |
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dc.contributor.author | Rovira, Jordi | - |
dc.contributor.author | Ramírez Bajo, María José | - |
dc.contributor.author | Bañon Maneus, Elisenda | - |
dc.contributor.author | Hierro García, Natalia | - |
dc.contributor.author | Lazo Rodríguez, Marta | - |
dc.contributor.author | Piñeiro, Gaston Julio | - |
dc.contributor.author | Montagud Marrahi, Enrique | - |
dc.contributor.author | Cucchiari, David | - |
dc.contributor.author | Revuelta, Ignacio | - |
dc.contributor.author | Cuatrecasas Freixas, Miriam | - |
dc.contributor.author | Campistol Plana, Josep M. | - |
dc.contributor.author | Ricart Brulles, Ma. José | - |
dc.contributor.author | Diekmann, Fritz | - |
dc.contributor.author | García Criado, Ángeles | - |
dc.contributor.author | Ventura Aguiar, Pedro | - |
dc.date.accessioned | 2024-01-24T13:36:55Z | - |
dc.date.available | 2024-01-24T13:36:55Z | - |
dc.date.issued | 2023-07-17 | - |
dc.identifier.issn | 1432-2277 | - |
dc.identifier.uri | http://hdl.handle.net/2445/206231 | - |
dc.description.abstract | Profiling of circulating immune cells provides valuable insight to the pathophysiology of acute rejection in organ transplantation. Herein we characterized the peripheral blood mononuclear cells in simultaneous kidney-pancreas transplant recipients. We conducted a retrospective analysis in a biopsy-matched cohort (n = 67) and compared patients with biopsy proven acute rejection (BPAR; 41%) to those without rejection (No-AR). We observed that CD3+ T cells, both CD8+ and CD4+, as well as CD19+ B cells were increased in patients with BPAR, particularly in biopsies performed in the early post-transplant period (<3 months). During this period immune subsets presented a good discriminative ability (CD4+ AUC 0.79; CD8+ AUC 0.80; B cells AUC 0.86; p < 0.05) and outperformed lipase (AUC 0.62; p = 0.12) for the diagnosis of acute rejection. We further evaluated whether this could be explained by differences in frequencies prior to transplantation. Patients presenting with early post-transplant rejection (<3 months) had a significant increase in T-cell frequencies pre-transplant, both CD4+ T cells and CD8+ T cells (p < 0.01), which were associated with a significant inferior rejection-free graft survival. T cell frequencies in peripheral blood correlated with pancreas acute rejection episodes, and variations prior to transplantation were associated with pancreas early acute rejection.Copyright © 2022 Rovira, Ramirez-Bajo, Bañón-Maneus, Hierro-Garcia, Lazo-Rodriguez, Piñeiro, Montagud-Marrahi, Cucchiari, Revuelta, Cuatrecasas, Campistol, Ricart, Diekmann, Garcia-Criado and Ventura-Aguiar. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/ti.2022.10639 | - |
dc.relation.ispartof | Transplant International, 2022, vol. 35 | - |
dc.relation.uri | https://doi.org/10.3389/ti.2022.10639 | - |
dc.rights | cc by (c) Rovira, Jordi et al, 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Trasplantament d'òrgans | - |
dc.subject.classification | Ronyó | - |
dc.subject.classification | Pàncrees | - |
dc.subject.other | Transplantation of organs | - |
dc.subject.other | Kidney | - |
dc.subject.other | Pancreas | - |
dc.title | Immune Profiling of Peripheral Blood Mononuclear Cells at Pancreas Acute Rejection Episodes in Kidney-Pancreas Transplant Recipients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-07-17T13:08:00Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9333147 | - |
dc.identifier.pmid | 36466442 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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File | Description | Size | Format | |
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Immune Profiling of Peripheral Blood Mononuclear Cells at Pancreas Acute Rejection_TransplantInternational.pdf | 2.57 MB | Adobe PDF | View/Open |
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