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http://hdl.handle.net/2445/206551
Title: | Occupational exposure to pesticides and endometrial cancer in the Screenwide case-control study |
Author: | Peñalver-Piñol, Arnau Benavente, Yolanda Frias Gomez, Jon Alguacil, Juan Santibáñez, Miguel Contreras Llanes, Manuel Peremiquel Trillas, Paula López-Querol Marta Paytubi Casabona, Sònia Pelegrina, Beatriz Onieva, Irene Martínez Delgado, José Manuel Fernandez Gonzalez, Sergi De Francisco, Javier Caño, Víctor Brunet, Joan Pineda Riu, Marta Ponce i Sebastià, Jordi Matias-Guiu, Xavier Bosch José, Francesc Xavier, 1947- Sanjosé, Silvia de Alemany i Vilches, Laia Costas, Laura |
Keywords: | Càncer d'endometri Plaguicides Accidents de treball Endometrial cancer Pesticides Industrial accidents |
Issue Date: | 2-Nov-2023 |
Publisher: | BioMed Central |
Abstract: | Background: Endometrial cancer is the most common gynaecological tumour in developed countries and disease burden is expected to increase over the years. Identifying modifiable risk factors may help developing strategies to reduce the expected increasing incidence of these neoplasms. Objective: This study evaluates the association between occupational exposure to pesticides and endometrial cancer using data from a recent case-control study in Spain. Methods: The analyses included data from 174 consecutive incident endometrial cancer cases and 216 hospital controls frequency-matched by age. Data were collected through structured epidemiological questionnaires and exposure to pesticides was assessed using a Spanish job-exposure matrix (MatEmESp). Results: Overall, 12% of controls and 18% of cases were occupationally exposed to pesticides. We observed a positive association between occupational exposure to pesticides and endometrial cancer (OR = 2.08; 95% CI = 1.13-3.88 compared to non-exposed). In general, exposures that occurred farther in the past were significantly associated with endometrial cancer. Exposure to insecticides, fungicides and herbicides were positively associated with endometrial cancer (OR = 2.08; 95% CI = 1.13-3.88, OR = 4.40; 95% CI = 1.65-13.33, and OR = 5.25; 95% CI = 1.84-17.67, respectively). The agricultural, poultry and livestock activities scenario was associated with endometrial cancer (OR = 4.16; 95% CI = 1.59-12.32), while the cleaning exposure scenario was not (OR = 1.22; 95% CI = 0.55-2.67). Conclusions: Assessment of occupational exposure to pesticides assessed using a Spanish job-exposure matrix revealed a positive association with endometrial cancer. The elucidation of the role of pesticide compounds on endometrial cancer should shed a light on the aetiology of this tumour. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s12940-023-01028-0 |
It is part of: | Environmental Health, 2023, vol. 22, p. 1-11 |
URI: | http://hdl.handle.net/2445/206551 |
Related resource: | https://doi.org/10.1186/s12940-023-01028-0 |
ISSN: | 1476-069X |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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