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DC Field | Value | Language |
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dc.contributor.author | Frade Sosa, Beatriz | - |
dc.contributor.author | Ponce, Andrés | - |
dc.contributor.author | Inciarte Mundo, José | - |
dc.contributor.author | Morla, Rosa | - |
dc.contributor.author | Ruíz Esquide, Virginia | - |
dc.contributor.author | Macías Muñoz, Laura | - |
dc.contributor.author | Azuaga, Ana Belén | - |
dc.contributor.author | Ramírez, Julio | - |
dc.contributor.author | Cañete Crespillo, Juan D. | - |
dc.contributor.author | Yagüe, Jordi | - |
dc.contributor.author | Auge, Josep Maria | - |
dc.contributor.author | Gómez Puerta, José A. | - |
dc.contributor.author | Sanmartí Sala, Raimon | - |
dc.date.accessioned | 2024-01-29T19:26:53Z | - |
dc.date.available | 2024-01-29T19:26:53Z | - |
dc.identifier.issn | 1759-7218 | - |
dc.identifier.uri | http://hdl.handle.net/2445/206552 | - |
dc.description.abstract | To analyse the accuracy of plasma calprotectin in patients with rheumatoid arthritis (RA) receiving monoclonal antibodies against IL-6 receptors (anti-rIL-6) or JAK inhibitors (JAKis) in detecting ultrasound (US) synovitis and compare it with acute phase reactants [high-sensitivity C-reactive protein (hs-CRP) and ESR].An observational cross-sectional study of RA patients receiving anti-rIL-6 (tocilizumab or sarilumab) or JAKi, (baricitinib or tofacitinib) was made. Plasma calprotectin for the diagnosis of US synovitis [synovial hypertrophy grade (SH)???2 plus power Doppler signal (PD)???1] was analysed using receiver operating characteristic curves (ROCs). The performance of ESR and hs-CRP was also studied. The three ROC curves were compared to determine which had the highest discriminatory power. Associations between plasma calprotectin and US scores were made using correlation analysis.Sixty-three RA patients were included. Mean plasma calprotectin levels were significantly higher in patients with US synovitis than in those without (0.89?±?0.85 vs 0.30?±?0.12 ?g/ml; p?=?0.0003). A moderate correlation between calprotectin and all US scores (HS score Rho?=?0.479; PD score Rho?=?0.492; and global score Rho?=?0.495) was found. The discriminatory capacity of plasma calprotectin showed an AUC of 0.795 (95% CI: 0.687-0.904). The AUC of hs-CRP and ESR was 0.721 and 0.564, respectively. hs-CRP serum levels showed a low positive correlation with the three US scores (Rho?<?0.40). After analysis according to the drugs administered, the correlation disappeared in patients receiving anti-rIL-6.Plasma calprotectin may be a sensitive biomarker of synovial inflammation in RA patients treated with anti-rIL-6 or JAKi.© The Author(s), 2022. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Sage | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1177/1759720x221114105 | - |
dc.relation.ispartof | Therapeutic Advances In Musculoskeletal Disease, 2022, vol. 14 | - |
dc.relation.uri | https://doi.org/10.1177/1759720x221114105 | - |
dc.rights | cc by-nc (c) Frade Sosa, Beatriz et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Artritis reumatoide | - |
dc.subject.classification | Anàlisi de proteïnes | - |
dc.subject.other | Rheumatoid arthritis | - |
dc.subject.other | Analysis of proteins | - |
dc.title | Plasma calprotectin as a biomarker of ultrasound synovitis in rheumatoid arthritis patients receiving IL-6 antagonists or JAK inhibitors | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-06-28T08:45:26Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9330850 | - |
dc.identifier.pmid | 36148395 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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