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http://hdl.handle.net/2445/206593
Title: | Dopamine neurotransmission and atypical antipsychotics in prefrontal cortex: a critical review |
Author: | Masana Nadal, Mercè Santana Ramos, Noemí Artigas Pérez, Francesc Bortolozzi Biasoni, Analía |
Keywords: | Escorça frontal Dopamina Trastorns de la cognició Antipsicòtics Prefrontal cortex Dopamine Cognition disorders Antipsychotic drugs |
Issue Date: | 31-Jul-2012 |
Publisher: | Bentham Science Publishers |
Abstract: | Schizophrenia has been historically characterized by the presence of positive symptomatology, however, decades of research highlight the importance of cognitive deficits in this disorder. At present, cognitive impairments remain one of the most important unmet therapeutic needs in schizophrenia. The prefrontal cortex (PFC) controls a large number of higher brain functions altered in a variety of psychiatric disorders, including schizophrenia. Histological studies indicate the presence of a large proportion of PFC neurons expressing monoaminergic receptors sensitive to the action of current atypical antipsychotics. Functional studies also show that these medications act at PFC level to increase dopamine neurotransmission in the mesocortical pathway. Here we focus on monoaminergic molecular targets that are actively being explored as potential therapeutic agents in the basic and clinical cognitive neuroscience research, to support the development of co-treatments used in conjunction with antipsychotic medications. These targets include dopamine and serotonin receptors in the prefrontal cortex, as well as elements of the noradrenergic system. |
Note: | Versió postprint del document publicat a: |
It is part of: | Current Topics In Medicinal Chemistry, 2012, vol. 12, num.21, p. 2357-2431 |
URI: | http://hdl.handle.net/2445/206593 |
ISSN: | 1568-0266 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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