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DC Field | Value | Language |
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dc.contributor.author | Ortiz-Prado, Esteban | - |
dc.contributor.author | Izquierdo-Condoy, Juan S. | - |
dc.contributor.author | Fernández Naranjo, Raúl | - |
dc.contributor.author | Vásconez González, Jorge Eduardo | - |
dc.contributor.author | Cano, Leonardo | - |
dc.contributor.author | González, Ana Carolina | - |
dc.contributor.author | Morales-Lapo, Estefanía | - |
dc.contributor.author | Guerrero-Castillo, Galo S. | - |
dc.contributor.author | Duque, Erick | - |
dc.contributor.author | Davila Rosero, Maria Gabriela | - |
dc.contributor.author | Egas, Diego | - |
dc.contributor.author | Viscor Carrasco, Ginés | - |
dc.date.accessioned | 2024-01-30T14:49:47Z | - |
dc.date.available | 2024-01-30T14:49:47Z | - |
dc.date.issued | 2023-12-29 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/206703 | - |
dc.description.abstract | Background Cardiovascular diseases, including ischemic heart disease, are the leading cause of prema- ture death and disability worldwide. While traditional risk factors such as smoking, obesity, and diabetes have been thoroughly investigated, non-traditional risk factors like high-alti- tude exposure remain underexplored. This study aims to examine the incidence and mortal- ity rates of ischemic heart disease over the past decade in Ecuador, a country with a diverse altitude profile spanning from 0 to 4,300 meters. Methods We conducted a geographic distribution analysis of ischemic heart disease in Ecuador, uti- lizing hospital discharge and mortality data from the National Institute of Census and Statis- tics for the years 2011–2021. Altitude exposure was categorized according to two distinct classifications: the traditional division into low (< 2,500 m) and high (> 2,500 m) altitudes, as well as the classification proposed by the International Society of Mountain Medicine, which delineates low (< 1,500 m), moderate (1,500–2,500 m), high (2,500–3,500 m), and very high (3,500–5,800 m) altitudes. Findings From 2011–2021, we analyzed 49,765 IHD-related hospital admissions and 62,620 deaths. Men had an age-adjusted incidence rate of 55.08/100,000 and a mortality rate of 47.2/ 100,000, compared to 20.77/100,000 and 34.8/100,000 in women. Incidence and mortality surged in 2020 by 83% in men and 75% in women. Altitudinal stratification revealed higher IHD rates at lower altitudes (<2500 m), averaging 61.65 and 121.8 per 100,000 for incidence and mortality, which declined to 25.9 and 38.5 at elevations >2500 m. Men had more pronounced rates across altitudes, exhibiting 138.7% and 150.0% higher incidence at low and high altitudes respectively, and mortality rates increased by 48.3% at low altitudes and 23.2% at high altitudes relative to women. Conclusion Ecuador bears a significant burden of ischemic heart disease (IHD), with men being more affected than women in terms of incidence. However, women have a higher percentage of mortality post-hospital admission. Regarding elevation, our analysis, using two different alti- tude cutoff points, reveals higher mortality rates in low-altitude regions compared to high- altitude areas, suggesting a potential protective effect of high elevation on IHD risk. Never- theless, a definitive dose-response relationship between high altitude and reduced IHD risk could not be conclusively established. | - |
dc.format.extent | 18 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0295586 | - |
dc.relation.ispartof | PLoS One, 2023, vol. 18, num.12, p. 1-18 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0295586 | - |
dc.rights | cc-by (c) Ortiz-Prado, E. et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Isquèmia | - |
dc.subject.classification | Influència de l'altitud | - |
dc.subject.classification | Equador | - |
dc.subject.classification | Malalties del cor | - |
dc.subject.other | Ischemia | - |
dc.subject.other | Influence of altitude | - |
dc.subject.other | Ecuador | - |
dc.subject.other | Heart diseases | - |
dc.title | Epidemiological characterization of ischemic heart disease at different altitudes: a nationwide population-based analysis from 2011 to 2021 in Ecuador | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 740612 | - |
dc.date.updated | 2024-01-30T14:49:47Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
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