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http://hdl.handle.net/2445/207100
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DC Field | Value | Language |
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dc.contributor.author | Laporta-Hoyos, Olga | - |
dc.contributor.author | Fiori, Simona | - |
dc.contributor.author | Pannek, Kerstin | - |
dc.contributor.author | Ballester Plané, Júlia | - |
dc.contributor.author | Leiva Ureña, David | - |
dc.contributor.author | Reid, Lee | - |
dc.contributor.author | Pagnozzi, Alex M. | - |
dc.contributor.author | Vázquez, Elida | - |
dc.contributor.author | Delgado, Ignacio | - |
dc.contributor.author | Macaya Ruiz, Alfons | - |
dc.contributor.author | Pueyo Benito, Roser | - |
dc.contributor.author | Boyd, Roslyn | - |
dc.date.accessioned | 2024-02-03T11:55:26Z | - |
dc.date.available | 2024-02-03T11:55:26Z | - |
dc.date.issued | 2018-06-20 | - |
dc.identifier.issn | 2213-1582 | - |
dc.identifier.uri | http://hdl.handle.net/2445/207100 | - |
dc.description.abstract | Purpose: To characterise brain lesions in dyskinetic cerebral palsy (DCP) using the semi-quantitative scale for structural MRI (sqMRI) and to investigate their relationship with motor, communication and cognitive function. Materials and methods: Thirty-nine participants (19 females, median age 21y) with DCP were assessed in terms of motor function, communication and a variety of cognitive domains. Whole-head magnetic resonance imaging (MRI) was performed including T1-MPRAGE, T2 turbo spin echo (axial plane), and fluid attenuated inversion recovery images (FLAIR). A child neurologist visually assessed images for brain lesions and scored these using the sqMRI. Ordinal, Poisson and binomial negative regression models identified which brain lesions accounted for clinical outcomes. Results: Brain lesions were most frequently located in the ventral posterior lateral thalamus and the frontal lobe. Gross (B = 0.180, p < .001; B = 0.658, p < .001) and fine (B = 0.136, p = .003; B = 0.540, p < .001) motor function were associated with global sqMRI score and parietal involvement. Communication functioning was associated with putamen involvement (B = 0.747, p < .028). Intellectual functioning was associated with global sqMRI score and posterior thalamus involvement (B = -0.018, p < .001; B = -0.192, p < .001). Selective attention was associated with global sqMRI score (B = -0.035, p < .001), parietal (B = -0.063, p = .023), and corpus callosum involvement (B = -0.448, p < .001). Visuospatial and visuoperceptive abilities were associated with global sqMRI score (B = -0.078, p = .007) and medial dorsal thalamus involvement (B = -0.139, p < .012), respectively. Conclusions: Key clinical outcomes in DCP are associated with specific observable brain lesions as indexed by a simple lesion scoring system that relies only on standard clinical MRI. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.nicl.2018.06.015 | - |
dc.relation.ispartof | Neuroimage-Clinical, 2018, vol. 19, p. 892-900 | - |
dc.relation.uri | https://doi.org/10.1016/j.nicl.2018.06.015 | - |
dc.rights | cc-by-nc-nd (c) Elsevier, 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) | - |
dc.subject.classification | Paràlisi cerebral | - |
dc.subject.classification | Imatges per ressonància magnètica | - |
dc.subject.classification | Cognició | - |
dc.subject.classification | Lesions cerebrals | - |
dc.subject.other | Cerebral palsy | - |
dc.subject.other | Magnetic resonance imaging | - |
dc.subject.other | Cognition | - |
dc.subject.other | Brain damage | - |
dc.title | Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 681420 | - |
dc.date.updated | 2024-02-03T11:55:26Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa) |
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210487.pdf | 1.86 MB | Adobe PDF | View/Open |
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