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http://hdl.handle.net/2445/207550
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DC Field | Value | Language |
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dc.contributor.author | Fernández-Nogueira, Patricia | - |
dc.contributor.author | Noguera Castells, Aleix | - |
dc.contributor.author | Fuster Orellana, Gemma | - |
dc.contributor.author | Recalde Percaz, Leire | - |
dc.contributor.author | Moragas, Núria | - |
dc.contributor.author | López Plana, Anna | - |
dc.contributor.author | Enreig, Estel | - |
dc.contributor.author | Jauregui, Patricia | - |
dc.contributor.author | Carbó Carbó, Neus | - |
dc.contributor.author | Almendro Navarro, Vanessa | - |
dc.contributor.author | Gascón, Pere | - |
dc.contributor.author | Bragado Domingo, Paloma | - |
dc.contributor.author | Mancino, Mario | - |
dc.date.accessioned | 2024-02-13T16:50:50Z | - |
dc.date.available | 2024-02-13T16:50:50Z | - |
dc.date.issued | 2018-06-28 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://hdl.handle.net/2445/207550 | - |
dc.description.abstract | Histamine receptor 1 (HRH1) belongs to the rhodopsin-like G-protein-coupled receptor family. Its activation by histamine triggers cell proliferation, embryonic development, and tumor growth. We recently established that HRH1 is up-regulated in basal and human epidermal growth factor receptor 2 (HER2)-enriched human breast tumors and that its expression correlates with a worse prognosis. Nevertheless, the functional role of HRH1 in basal and HER2-targeted therapy-resistant breast cancer (BC) progression has not yet been addressed. Using terfenadine, a selective chemical inhibitor of HRH1, we showed that the inhibition of HRH1 activity in basal BC cells leads to sub-G0 cell accumulation, suppresses proliferation, promotes cell motility and triggers the activation of extracellular signal-regulated kinase (ERK) signaling, initiating the mitochondrial apoptotic pathway. Furthermore, HER2-targeted therapy-resistant cells express higher levels of HRH1 and are more sensitive to terfenadine treatment. Moreover, in vivo experiments showed that terfenadine therapy reduced the tumor growth of basal and trastuzumab-resistant BC cells. In conclusion, our results suggest that targeting HRH1 is a promising new clinical approach to consider that could enhance the effectiveness of current therapeutic treatment in patients with basal and BC tumors resistant to HER2-targeted therapies. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.canlet.2018.03.014 | - |
dc.relation.ispartof | Cancer Letters, 2018, vol. 424, p. 70-83 | - |
dc.relation.uri | https://doi.org/10.1016/j.canlet.2018.03.014 | - |
dc.rights | cc-by-nc-nd (c) Fernandez-Nogueira, Patricia et al., 2018 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Receptors cel·lulars | - |
dc.subject.classification | Apoptosi | - |
dc.subject.classification | Neuropèptids | - |
dc.subject.classification | Inhibidors enzimàtics | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Histamina | - |
dc.subject.other | Cell receptors | - |
dc.subject.other | Apoptosis | - |
dc.subject.other | Neuropeptides | - |
dc.subject.other | Enzyme inhibitors | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Histamine | - |
dc.title | Histamine receptor 1 inhibition enhances antitumor therapeutic responses through extracellular signal-regulated kinase (ERK) activation in breast cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 690105 | - |
dc.date.updated | 2024-02-13T16:50:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29548821 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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