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http://hdl.handle.net/2445/207749
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DC Field | Value | Language |
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dc.contributor.author | Erton, Zeynep Belce | - |
dc.contributor.author | Sevim, Ecem | - |
dc.contributor.author | de Jesús, Guilherme Ramires | - |
dc.contributor.author | Cervera i Segura, Ricard, 1960- | - |
dc.contributor.author | Ji, Lan Lan | - |
dc.contributor.author | Pengo, Vittorio | - |
dc.contributor.author | Ugarte, Amaia | - |
dc.contributor.author | Andrade, Danieli | - |
dc.contributor.author | Andreoli, Laura | - |
dc.contributor.author | Atsumi, Tatsuya | - |
dc.contributor.author | Fortin, Paul R. | - |
dc.contributor.author | Gerosa, Maria | - |
dc.contributor.author | Zuo, Yu | - |
dc.contributor.author | Petri, Michelle | - |
dc.contributor.author | Sciascia, Savino | - |
dc.contributor.author | Tektonidou, Maria | - |
dc.contributor.author | Aguirre Zamorano, Mª. Ángeles | - |
dc.contributor.author | Branch, D Ware | - |
dc.contributor.author | Erkan, Doruk | - |
dc.date.accessioned | 2024-02-19T18:54:04Z | - |
dc.date.available | 2024-02-19T18:54:04Z | - |
dc.date.issued | 2022-06-14 | - |
dc.identifier.issn | 2053-8790 | - |
dc.identifier.uri | http://hdl.handle.net/2445/207749 | - |
dc.description.abstract | Objectives: To describe the outcomes of pregnancies in antiphospholipid antibody (aPL)-positive patients since the inception of the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking Registry. Methods: We identified persistently aPL-positive patients recorded as 'pregnant' during prospective follow-up, and defined 'aPL-related outcome' as a composite of: (1) Preterm live delivery (PTLD) at or before 37th week due to pre-eclampsia (PEC), eclampsia, small-for-gestational age (SGA) and/or placental insufficiency (PI); or (2) Otherwise unexplained fetal death after the 10th week of gestation. The primary objective was to describe the characteristics of patients with and without aPL-related composite outcomes based on their first observed pregnancies following registry recruitment. Results: Of the 55 first pregnancies observed after registry recruitment among nulliparous and multiparous participants, 15 (27%) resulted in early pregnancy loss <10 weeks gestation. Of the remaining 40 pregnancies: (1) 26 (65%) resulted in term live delivery (TLD), 4 (10%) in PTLD between 34.0 weeks and 36.6 weeks, 5 (12.5%) in PTLD before 34th week, and 5 (12.5%) in fetal death (two associated with genetic anomalies); and (2) The aPL-related composite outcome occurred in 9 (23%). One of 26 (4%) pregnancies with TLD, 3/4 (75%) with PTLD between 34.0 weeks and 36.6 weeks, and 3/5 (60%) with PTLD before 34th week were complicated with PEC, SGA and/or PI. Fifty of 55 (91%) pregnancies were in lupus anticoagulant positive subjects, as well as all pregnancies with aPL-related composite outcome. Conclusion: In our multicentre, international, aPL-positive cohort, of 55 first pregnancies observed prospectively, 15 (27%) were complicated by early pregnancy loss. Of the remaining 40 pregnancies, composite pregnancy morbidity was observed in 9 (23%) pregnancies. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1136/lupus-2021-000633 | - |
dc.relation.ispartof | Lupus Science & Medicine, 2022, vol. 9, num.1, e000633 | - |
dc.relation.uri | https://doi.org/10.1136/lupus-2021-000633 | - |
dc.rights | cc-by-nc (c) Erton ZB et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Embaràs | - |
dc.subject.classification | Mort del fetus | - |
dc.subject.classification | Avortament | - |
dc.subject.classification | Lupus eritematós | - |
dc.subject.classification | Síndrome antifosfolipídica | - |
dc.subject.classification | Assaigs clínics | - |
dc.subject.other | Pregnancy | - |
dc.subject.other | Fetal death | - |
dc.subject.other | Abortion | - |
dc.subject.other | Lupus erythematosus | - |
dc.subject.other | Antiphospholipid syndrome | - |
dc.subject.other | Clinical trials | - |
dc.title | Pregnancy outcomes in antiphospholipid antibody positive patients: prospective results from the AntiPhospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository ('Registry'). | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 731011 | - |
dc.date.updated | 2024-02-19T18:54:04Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9354696 | - |
dc.identifier.pmid | 35701043 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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