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Title: | Soluble Transferrin Receptor as Iron Deficiency Biomarker: Impact on Exercise Capacity in Heart Failure Patients |
Author: | Ras Jiménez, Maria del Mar Ramos Polo, Raúl Francesch Manzano, Josep Corbella Santano, Miriam Morillas Climent, Herminio Jose Bazán, Núria Jiménez Marrero, Santiago Garcimartin Cerezo, Paloma Yun Viladomat, Sergi Moliner Borja, Pedro Torres Cardús, Blanca Verdú Rotellar, José Maria Diez López, Carles González Costello, José García Romero, Elena Frutos Seminario, Fernando de Triguero Llonch, Laura Enjuanes Grau, Cristina Tajes Orduña, Marta Comin Colet, Josep |
Keywords: | Dèficit de ferro Marcadors bioquímics Iron deficiency diseases Biochemical markers |
Issue Date: | 21-Aug-2023 |
Publisher: | MDPI AG |
Abstract: | The soluble transferrin receptor (sTfR) is a marker of tissue iron status, which could indicate an increased iron demand at the tissue level. The impact of sTfR levels on functional capacity and quality of life (QoL) in non-anemic heart failure (HF) patients with otherwise normal systemic iron status has not been evaluated. We conducted an observational, prospective, cohort study of 1236 patients with chronic HF. We selected patients with normal hemoglobin levels and normal systemic iron status. Tissue iron deficiency (ID) was defined as levels of sTfR > 75th percentile (1.63 mg per L). The primary endpoints were the distance walked in the 6 min walking test (6MWT) and the overall summary score (OSS) of the Minnesota Living with Heart Failure Questionnaire (MLHFQ). The final study cohort consisted of 215 patients. Overall QoL was significantly worse (51 +/- 27 vs. 39 +/- 20, p-value = 0.006, respectively), and the 6 MWT distance was significantly worse in patients with tissue ID when compared to patients without tissue ID (206 +/- 179 m vs. 314 +/- 155, p-value < 0.0001, respectively). Higher sTfR levels, indicating increased iron demand, were associated with a shorter distance in the 6 MWT (standardized beta = -0.249, p < 0.001) and a higher MLHFQ OSS (standardized fi = 0.183, p-value = 0.008). In this study, we show that in patients with normal systemic iron parameters, higher levels of sTfR are strongly associated with an impaired submaximal exercise capacity and with worse QoL. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jpm13081282 |
It is part of: | Journal of Personalized Medicine, 2023, vol. 13, num. 8 |
URI: | http://hdl.handle.net/2445/207858 |
Related resource: | https://doi.org/10.3390/jpm13081282 |
ISSN: | 2075-4426 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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