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Title: | The Etiology, Antibiotic Therapy and Outcomes of Bacteremic Skin and Soft-Tissue Infections in Onco-HematologicalPatients. Antibiotics (Basel). |
Author: | Castelli, Valeria Sastre-escolà, Enric Puerta-Alcalde, Pedro Huete-Álava, Leyre Laporte Amargós, Júlia Bergas, Alba Chumbita, Mariana Marín, Mar Domingo Domènech, Eva Badia-Tejero, Ana María Pons-Oltra, Paula Garcia Vidal, Carolina Carratalà, Jordi Gudiol González, Carlota |
Keywords: | Bacteris gramnegatius Resistència als medicaments Càncer Gram-negative bacteria Drug resistance Cancer |
Issue Date: | 13-Dec-2023 |
Publisher: | MDPI |
Abstract: | Objectives: to assess the current epidemiology, antibiotic therapy and outcomes of oncohematological patients with bacteremic skin and soft-tissue infections (SSTIs), and to identify the risk factors for Gram-negative bacilli (GNB) infection and for early and overall mortality. Methods: episodes of bacteremic SSTIs occurring in cancer patients at two hospitals were prospectively recorded and retrospectively analyzed. Results: Of 164 episodes of bacteremic SSTIs, 53% occurred in patients with solid tumors and 47% with hematological malignancies. GNB represented 45.5% of all episodes, led by Pseudomonas aeruginosa (37.8%). Multidrug resistance rate was 16%. Inadequate empirical antibiotic therapy (IEAT) occurred in 17.7% of episodes, rising to 34.6% in those due to resistant bacteria. Independent risk factors for GNB infection were corticosteroid therapy and skin necrosis. Early and overall case-fatality rates were 12% and 21%, respectively. Risk factors for early mortality were older age, septic shock, and IEAT, and for overall mortality were older age, septic shock and resistant bacteria. Conclusions: GNB bacteremic SSTI was common, particularly if corticosteroid therapy or skin necrosis. IEAT was frequent in resistant bacteria infections. Mortality occurred mainly in older patients with septic shock, resistant bacteria and IEAT. These results might guide empirical antibiotic therapy in this high-risk population. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/antibiotics12121722 |
It is part of: | Antibiotics, 2023, vol. 12, num.12, p. 1722 |
URI: | http://hdl.handle.net/2445/207936 |
Related resource: | https://doi.org/10.3390/antibiotics12121722 |
ISSN: | 2079-6382 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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