Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/207941
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hurtado Navarro, Laura | - |
dc.contributor.author | Cuenca Zamora, Ernesto José | - |
dc.contributor.author | Zamora, Lurdes | - |
dc.contributor.author | Bellosillo, Beatriz | - |
dc.contributor.author | Such, Esperanza | - |
dc.contributor.author | Soler Espejo, Eva | - |
dc.contributor.author | Martínez Banaclocha, Helios | - |
dc.contributor.author | Hernández Rivas, Jesús M. | - |
dc.contributor.author | Marco Ayala, Javier | - |
dc.contributor.author | Martínez Alarcón, Laura | - |
dc.contributor.author | Linares Latorre, Lola | - |
dc.contributor.author | García Ávila, Sara | - |
dc.contributor.author | Amat Martínez, Paula | - |
dc.contributor.author | González, Teresa | - |
dc.contributor.author | Arnan, Montserrat | - |
dc.contributor.author | Pomares Marín, Helena | - |
dc.contributor.author | Carreño Tarragona, Gonzalo | - |
dc.contributor.author | Chen Liang, Tzu Hua | - |
dc.contributor.author | Herranz, María T. | - |
dc.contributor.author | García Palenciano, Carlos | - |
dc.contributor.author | Morales, María Luz | - |
dc.contributor.author | Jerez, Andrés | - |
dc.contributor.author | Lozano, María L. | - |
dc.contributor.author | Teruel Montoya, Raúl | - |
dc.contributor.author | Pelegrín, Pablo | - |
dc.contributor.author | Ferrer Marín, Francisca | - |
dc.date.accessioned | 2024-02-22T10:10:14Z | - |
dc.date.available | 2024-02-22T10:10:14Z | - |
dc.date.issued | 2023-12-19 | - |
dc.identifier.issn | 2666-3791 | - |
dc.identifier.uri | http://hdl.handle.net/2445/207941 | - |
dc.description.abstract | Chronic myelomonocytic leukemia (CMML) is frequently associated with mutations in the rat sarcoma gene (RAS), leading to worse prognosis. RAS mutations result in active RAS-GTP proteins, favoring myeloid cell proliferation and survival and inducing the NLRP3 inflammasome together with the apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), which promote caspase-1 activation and interleukin (IL)-1(3 release. Here, we report, in a cohort of CMML patients with mutations in KRAS, a constitutive activation of the NLRP3 inflammasome in monocytes, evidenced by ASC oligomerization and IL-1(3 release, as well as a specific inflammatory cytokine signature. Treatment of a CMML patient with a KRASG12D mutation using the IL-1 receptor blocker anakinra inhibits NLRP3 inflammasome activation, reduces monocyte count, and improves the patient's clinical status, enabling a stem cell transplant. This reveals a basal inflammasome activation in RAS-mutated CMML patients and suggests potential therapeutic applications of NLRP3 and IL-1 blockers. | - |
dc.format.extent | 17 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.xcrm.2023.101329 | - |
dc.relation.ispartof | Cell Reports Medicine, 2023, vol. 4, num. 12 | - |
dc.relation.uri | https://doi.org/10.1016/j.xcrm.2023.101329 | - |
dc.rights | cc by-nc-nd (c) Hurtado Navarro, Laura et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Leucèmia | - |
dc.subject.classification | Citocines | - |
dc.subject.other | Leukemia | - |
dc.subject.other | Cytokines | - |
dc.title | NLRP3 inflammasome activation and symptom burden in KRAS-mutated CMML patients is reverted by IL-1 blocking therapy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2024-02-19T10:40:40Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 38118408 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
PIIS2666379123005463.pdf | 4.2 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License