Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/208383
Title: | UP-DOWN cortical dynamics reflect state transitions in a bistable network. |
Author: | Jercog, D. Roxin, Alex Compte Braquets, Albert de la Rocha, J. |
Keywords: | Anestèsia Mapatge del cervell Anesthesia Brain Mapping |
Issue Date: | 4-Aug-2017 |
Publisher: | eLife Sciences Publications, Ltd |
Abstract: | In the idling brain, neuronal circuits transition between periods of sustained firing (UP state) and quiescence (DOWN state), a pattern the mechanisms of which remain unclear. Here we analyzed spontaneous cortical population activity from anesthetized rats and found that UP and DOWN durations were highly variable and that population rates showed no significant decay during UP periods. We built a network rate model with excitatory (E) and inhibitory (I) populations exhibiting a novel bistable regime between a quiescent and an inhibition-stabilized state of arbitrarily low rate. Fluctuations triggered state transitions, while adaptation in E cells paradoxically caused a marginal decay of E-rate but a marked decay of I-rate in UP periods, a prediction that we validated experimentally. A spiking network implementation further predicted that DOWN-to-UP transitions must be caused by synchronous high-amplitude events. Our findings provide evidence of bistable cortical networks that exhibit non-rhythmic state transitions when the brain rests. |
Note: | Reproducció del document publicat a: https://doi.org/10.7554/elife.22425 |
It is part of: | Elife, 2017, vol. 6 |
URI: | http://hdl.handle.net/2445/208383 |
Related resource: | https://doi.org/10.7554/elife.22425 |
ISSN: | 2050-084X |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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eLife.22425.pdf | 2.58 MB | Adobe PDF | View/Open |
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