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http://hdl.handle.net/2445/208469
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DC Field | Value | Language |
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dc.contributor.author | Escrihuela Vidal, Francesc | - |
dc.contributor.author | Berbel, Dàmaris | - |
dc.contributor.author | Fernández Hidalgo, Nuria | - |
dc.contributor.author | Escolà Vergé, Laura | - |
dc.contributor.author | Muñoz, Patricia | - |
dc.contributor.author | Olmedo Samperio, María | - |
dc.contributor.author | Goenaga Sánchez, Miguel Ángel | - |
dc.contributor.author | Goikoetxea Agirre, Ane Josune | - |
dc.contributor.author | Fariñas, María Carmen | - |
dc.contributor.author | Alarcón, Aristides de | - |
dc.contributor.author | Miró Meda, José M. | - |
dc.contributor.author | Ojeda Burgos, Guillermo | - |
dc.contributor.author | Plata, Antonio | - |
dc.contributor.author | Cuervo Requena, Guillermo | - |
dc.contributor.author | Carratalà, Jordi | - |
dc.contributor.author | GAMES Investigators. | - |
dc.date.accessioned | 2024-03-06T16:26:31Z | - |
dc.date.available | 2024-06-22T05:10:25Z | - |
dc.date.issued | 2023-06-22 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.uri | http://hdl.handle.net/2445/208469 | - |
dc.description.abstract | Background: Evidence supporting combination treatment with a beta-lactam plus an aminoglycoside (C-BA) for endocarditis caused by viridans and gallolyticus group streptococci (VGS-GGS) with intermediate susceptibility to penicillin (PENI-I) is lacking. We assessed the clinical characteristics and outcomes of PEN-I VGS-GGS endocarditis and compared the effectiveness and safety of C-BA with third-generation cephalosporin monotherapy. Methods: Retrospective analysis of prospectively collected data of a cohort of definite endocarditis caused by penicillin-susceptible and PENI-I VGS-GGS (penicillin minimum inhibitory concentration ranging from 0.25 to 2 mg/L) between 2008 and 2018 in 40 Spanish hospitals. We compared cases treated with monotherapy or with C-BA and performed multivariable analyses of risk factors for in-hospital and 1-year mortality. Results: A total of 914 consecutive cases of definite endocarditis caused by VGS-GGS with complete or intermediate susceptibility to penicillin were included. A total of 688 (75.3%) were susceptible to penicillin and 226 (24.7%) were PENI-I. Monotherapy was used in 415 (45.4%) cases (cephalosporin in 331 cases) and 499 (54.6%) cases received C-BA. In-hospital mortality was 11.9%, and 190 (20.9%) patients developed acute kidney injury. Heart failure (odds ratio [OR]: 6.06; 95% confidence interval [CI]: 1.37-26.87; P = .018), central nervous system emboli (OR: 9.83; 95% CI: 2.17-44.49; P = .003) and intracardiac abscess (OR: 13.47; 95% CI: 2.24-81.08; P = .004) were independently associated with in-hospital mortality among PEN-I VGS-GGS cases, while monotherapy was not (OR: 1.01; 95% CI: .26-3.96; P = .982). Conclusions: Our findings support the use of cephalosporin monotherapy in PEN-I VGS-GGS endocarditis in order to avoid nephrotoxicity without adversely affecting patient outcomes. | - |
dc.format.extent | 26 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1093/cid/ciad375 | - |
dc.relation.ispartof | Clinical Infectious Diseases, 2023, vol. 77, num.9, p. 1273-1281 | - |
dc.relation.uri | https://doi.org/10.1093/cid/ciad375 | - |
dc.rights | (c) Escrihuela-Vidal, F. et al., 2023 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Infeccions per estreptococs | - |
dc.subject.classification | Cefalosporines | - |
dc.subject.classification | Medicaments antibacterians | - |
dc.subject.classification | Penicil·lina | - |
dc.subject.classification | Endocarditis | - |
dc.subject.other | Streptococcal infections | - |
dc.subject.other | Cephalosporines | - |
dc.subject.other | Antibacterial agents | - |
dc.subject.other | Penicillin | - |
dc.subject.other | Endocarditis | - |
dc.title | Impact of Intermediate Susceptibility to Penicillin on Antimicrobial Treatment and Outcomes of Endocarditis Caused by Viridans and Gallolyticus Group Streptococci | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 740894 | - |
dc.date.updated | 2024-03-06T16:26:31Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9374397 | - |
dc.identifier.pmid | 37345869 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
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836872.pdf | 574.25 kB | Adobe PDF | View/Open |
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