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http://hdl.handle.net/2445/208644
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DC Field | Value | Language |
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dc.contributor.author | Weiderpass, Elisabete | - |
dc.contributor.author | Nimptsch, Katharina | - |
dc.contributor.author | Aleksandrova, Krasimira | - |
dc.contributor.author | Pham, Thu Thi | - |
dc.contributor.author | Papadimitriou, Nikos | - |
dc.contributor.author | Janke, Jürgen | - |
dc.contributor.author | Christakoudi, Sofia | - |
dc.contributor.author | Heath, Alicia K. | - |
dc.contributor.author | Olsen, Anja | - |
dc.contributor.author | Tjønneland, Anne | - |
dc.contributor.author | Schulze, Matthias B. | - |
dc.contributor.author | Katzke, Verena | - |
dc.contributor.author | Kaaks, Rudolf | - |
dc.contributor.author | Van Guelpen, Bethany | - |
dc.contributor.author | Harbs, Justin | - |
dc.contributor.author | Palli, Domenico | - |
dc.contributor.author | Macciotta, Alessandra | - |
dc.contributor.author | Pasanisi, Fabrizio | - |
dc.contributor.author | Colorado Yohar, Sandra M. | - |
dc.contributor.author | Guevara, Marcela | - |
dc.contributor.author | Amiano, Pilar | - |
dc.contributor.author | Grioni, Sara | - |
dc.contributor.author | Jakszyn, Paula | - |
dc.contributor.author | Figueiredo, Jane C. | - |
dc.contributor.author | Samadder, N. Jewel | - |
dc.contributor.author | Li, Christopher I. | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.contributor.author | Potter, John D. | - |
dc.contributor.author | Schoen, Robert E. | - |
dc.contributor.author | Um, Caroline Y. | - |
dc.contributor.author | Jenab, Mazda | - |
dc.contributor.author | Gunter, Marc J. | - |
dc.contributor.author | Pischon, Tobias | - |
dc.date.accessioned | 2024-03-11T18:06:29Z | - |
dc.date.available | 2024-03-11T18:06:29Z | - |
dc.date.issued | 2023-10-13 | - |
dc.identifier.issn | 1741-7015 | - |
dc.identifier.uri | http://hdl.handle.net/2445/208644 | - |
dc.description.abstract | Background: Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation and may thus play a role in colorectal cancer (CRC) development. We aimed to investigate the association between circulating FABP-4 and CRC and to assess potential causality using a Mendelian randomization (MR) approach. Methods: The association between pre-diagnostic plasma measurements of FABP-4 and CRC risk was investigated in a nested case-control study in 1324 CRC cases and the same number of matched controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A two-sample Mendelian randomization study was conducted based on three genetic variants (1 cis, 2 trans) associated with circulating FABP-4 identified in a published genome-wide association study (discovery n = 20,436) and data from 58,131 CRC cases and 67,347 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. Results: In conditional logistic regression models adjusted for potential confounders including body size, the estimated relative risk, RR (95% confidence interval, CI) per one standard deviation, SD (8.9 ng/mL) higher FABP-4 concentration was 1.01 (0.92, 1.12) overall, 0.95 (0.80, 1.13) in men and 1.09 (0.95, 1.25) in women. Genetically determined higher FABP-4 was not associated with colorectal cancer risk (RR per FABP-4 SD was 1.10 (0.95, 1.27) overall, 1.03 (0.84, 1.26) in men and 1.21 (0.98, 1.48) in women). However, in a cis-MR approach, a statistically significant association was observed in women (RR 1.56, 1.09, 2.23) but not overall (RR 1.23, 0.97, 1.57) or in men (0.99, 0.71, 1.37). Conclusions: Taken together, these analyses provide no support for a causal role of circulating FABP-4 in the development of CRC, although the cis-MR provides some evidence for a positive association in women, which may deserve to be investigated further. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12916-023-03104-1 | - |
dc.relation.ispartof | BMC Medicine, 2023, vol. 21, num.1 | - |
dc.relation.uri | https://doi.org/10.1186/s12916-023-03104-1 | - |
dc.rights | cc-by (c) Nimptsch, K. et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Àcids grassos | - |
dc.subject.classification | Genètica | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Fatty acids | - |
dc.subject.other | Genetics | - |
dc.title | Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 743677 | - |
dc.date.updated | 2024-03-11T18:06:29Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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845358.pdf | 1.04 MB | Adobe PDF | View/Open |
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