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DC Field | Value | Language |
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dc.contributor.author | Domínguez López, Inés | - |
dc.contributor.author | Arancibia Riveros, Camila | - |
dc.contributor.author | Casas Rodríguez, Rosa M. | - |
dc.contributor.author | Tresserra i Rimbau, Anna | - |
dc.contributor.author | Razquin, Cristina | - |
dc.contributor.author | Martínez-González, Miguel Ángel, 1957- | - |
dc.contributor.author | Hu, Frank B. | - |
dc.contributor.author | Ros Rahola, Emilio | - |
dc.contributor.author | Fitó Colomer, Montserrat | - |
dc.contributor.author | Estruch Riba, Ramon | - |
dc.contributor.author | López Sabater, María del Carmen | - |
dc.contributor.author | Lamuela Raventós, Rosa Ma. | - |
dc.date.accessioned | 2024-03-14T13:52:09Z | - |
dc.date.available | 2024-03-14T13:52:09Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/208782 | - |
dc.description.abstract | Systemic inflammation is associated with an increased risk of non-communicable diseases, such as cardiovascular diseases and diabetes. Circulating fatty acids (FA) are known to be related to these conditions, possibly through their role in inflammation, although different types of FAs can have opposite effects on inflammatory mediators. The aim of the present study was to analyze the association of plasma FAs with inflammatory biomarkers in a PREDIMED trial subsample after one year of intervention. In a one-year longitudinal study of 91 participants of the PREDIMED trial (Barcelona-Clinic center), plasma FAs and inflammatory biomarkers were analyzed using gas chromatography and ELISA, respectively. In baseline plasma, a multivariable-adjusted ordinary least squares regression model showed that n-3 polyunsaturated FAs concentrations were inversely associated with concentrations of soluble intercellular adhesion molecule-1 (sICAM-1) and E-selectin, whereas the level of the most abundant saturated FA, palmitic acid, was directly associated with concentrations of interleukin-6 (IL-6) (β = 0.48 pg/mL, 95% CI: 0.03, 0.93 per 1-SD increase, p-value = 0.037). After one year of nutritional intervention, changes of plasma diet-derived total saturated FAs and palmitic acid were directly associated with changes in IL-6 (β = 0.59 pg/mL [95% CI: 0.28, 0.89] per 1-SD, p-value = 0.001; β = 0.64 pg/mL, 95% CI: 0.31, 0.98, p-value = 0.001), respectively, after correction for multiple testing. Our findings suggest that saturated FAs of dietary origin, especially palmitic acid, are directly involved in the increase of IL-6 in plasma. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Masson SAS | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.biopha | - |
dc.relation.ispartof | Biomedicine & Pharmacotherapy, 2022, vol. 150 | - |
dc.relation.uri | https://doi.org/10.1016/j.biopha | - |
dc.rights | cc by (c) Domínguez López, Inés et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Plasma sanguini | - |
dc.subject.classification | Cuina mediterrània | - |
dc.subject.classification | Àcids grassos saturats | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Malalties cardiovasculars | - |
dc.subject.classification | Diabetis | - |
dc.subject.other | Blood plasma | - |
dc.subject.other | Mediterranean cooking | - |
dc.subject.other | Saturated fatty acids | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Cardiovascular diseases | - |
dc.subject.other | Diabetes | - |
dc.title | Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 723119 | - |
dc.date.updated | 2024-03-14T13:52:09Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9308303 | - |
dc.identifier.pmid | 35483198 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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